Project Grant R01MH137441

Award Date 4/15/25
Completion Date 3/31/30
Dollars Obligated $792K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Belmont, MA 02478, USA
Similar Awards
This Project Grant award from the National Institute of Mental Health (NIMH), CFDA 93.242 Mental Health Research Grants program, will support a $759,581 research study to develop personalized machine learning approaches to predict states of high negative affective (NA) states (e.g. sadness, anger, anxiety) in the daily lives of adolescents aged 12-16. The study will collect passive smartphone sensor data on activity levels, location, phone/screen use, calls/texts, and sleep to test the...
This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research focused on understanding the neurocircuitry underlying motivated reward-seeking behavior following exposure to stress. The $606,029 award to the University of Massachusetts Medical School aims to elucidate the role of the medial habenulo-interpeduncular nucleus (MHB-IPN) axis in modulating reward-seeking as a coping...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $249,000.00 to investigate the neurobiological, genetic, and environmental factors that contribute to the development of depression in children at high family risk. The research will examine whether measures of hippocampal structure and function, as well as cumulative genetic risk, predict individual differences in susceptibility versus...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to characterize the role of multisystemic biological stress response mechanisms in the severity and trajectory of anhedonia (reduced ability to experience pleasure) during adolescence. The $770,483 award to the University of North Carolina at Chapel Hill will fund a longitudinal study of 192 adolescents aged 13-15 years. The study will use...
This Project Grant award of $114,899, made by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the neurocomputational mechanisms underlying how individuals strategically allocate mental effort in the face of sustained stress. The primary objectives are to: 1) use computational modeling to identify the sub-processes that reflect the aversiveness and controllability of sustained stressors during mental...
This $165,980 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a research study examining neural indices of social and monetary reward processing as predictors of real-world pleasure and affect in adolescents at risk for depression. The study aims to determine whether laboratory-based measures of reward outcome processing can predict daily levels of consummatory pleasure and affect among adolescents...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) totaling $1,611,022 will support a longitudinal study on adolescent brain maturation and its relationship to psychiatric disorders. The University of Pittsburgh will conduct the research, which aims to examine neuropil growth/contraction and multiplex network dysconnectivity in adolescents, and their association with categorical (mental health diagnoses)...
This $535,153 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a large-scale, single-cell characterization of molecular and cellular networks of mood regulation circuitry in major depressive disorder (MDD). The research aims to: 1) identify transcriptomic changes associated with MDD at the single-cell level across three brain regions (anterior cingulate cortex, basolateral amygdala, and hippocampus),...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $195,000 in funding to the Research Institute at Nationwide Children's Hospital (RINCH) from May 1, 2025 to April 30, 2027. The project aims to characterize the role of sleep brain dynamics in the emergence of depression in adolescents. Specifically, the study will: (1) identify the space-time profiles of sleep slow oscillations and...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to chart positive valence systems trajectories in offspring of depressed mothers to predict internalizing symptoms in early childhood. The $801,869 award, effective from Sep 1, 2024 to Jun 30, 2029, will use an innovative, multimodal, accelerated longitudinal design to assess neural and behavioral indicators of reward responsiveness in a...

This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $792,441 to investigate the relationship between stress responses and risk of depression in female adolescents with and without a parental history of major depressive disorder (MDD).

The key objectives are to: 1) Assess changes in dynamic brain network properties, specifically in the default mode network (DMN) and central executive network (CEN), before and after an acute psychosocial stressor; 2) Measure associated physiological and behavioral stress responses using wearable devices and self-report, and; 3) Determine if this maladaptive stress response profile predicts future MDD onset in the 18-month follow-up period. The award period runs from April 15, 2025 to March 31, 2030 and will be conducted by the Mclean Hospital Corporation, a non-profit psychiatric research center affiliated with Harvard Medical School.

Generated 4/29/25, 2:56 AM