This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding research at The Johns Hopkins University to investigate the role of reward mechanisms in hippocampal memory formation. The $242,310 award, with a period of performance from Sep 5, 2024 to Mar 31, 2026, will support in vivo electrophysiology studies in rats to explore how reward expectation and delivery influence head scanning behavior and...
The National Institute of Mental Health (NIMH) awarded a $633,438 Project Grant (CFDA 93.242 - Mental Health Research Grants) to New York University (NYU) to develop a data-driven framework for real-time neural control and targeted modulation of prefrontal cortical circuits in primates. The research aims to uncover the principles governing multi-electrode microstimulation responses, introduce a novel algorithm for predicting optimal stimulation patterns to evoke specific neural activity...
This $2,306,736 federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the neural mechanisms underlying value-guided decision-making and learning. The primary awardee, the Regents of the University of California, San Francisco (UCSF), will employ advanced recording techniques and an innovative foraging task to test two key hypotheses: 1) that post-reward sharp-wave-ripple...
This Project Grant award of $760,143 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at the University of Maryland, Baltimore (UMB) on the role of endocannabinoid signaling in modulating cholinergic transmission and reward-seeking behavior. The project aims to investigate how the deletion of cannabinoid type 1 (CB1) receptors specifically on cholinergic terminals in the hippocampus affects working memory...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the synaptic plasticity mechanisms that regulate the growth, refinement, and recovery of neural circuits underlying learning and memory. The $466,757 award, effective September 1, 2024 through August 31, 2025, will be conducted by the University of Texas at Austin. The research aims to: 1) Determine the specificity...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the claustrum, a subcortical brain region, in flexible decision-making behaviors. The $608,309 award to The Johns Hopkins University, with a performance period from December 2024 to December 2025, will test the hypothesis that the claustrum contributes to generating and maintaining persistent cortical...
This $189,540 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research conducted by the University of Pittsburgh to investigate the neural circuitry underlying model-based decision-making. The 5-year grant, awarded on February 1, 2025, aims to determine how distinct cell types in the prelimbic cortex and dorsomedial striatum represent and coordinate model-based control processes that allow...
This $197,235 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a four-year research career development program investigating the circuit physiology of cognitive flexibility. The funded research aims to study how acetylcholine signaling in the basal forebrain regulates reward-based reversal learning and behavioral flexibility, which has relevance for mental disorders like schizophrenia, autism...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants aims to advance the understanding of the neurocircuitry and mechanisms underlying motivated reward-seeking behavior as a coping strategy for stress. The $606,029 award to the University of Massachusetts Medical School will fund a 1-year research project to investigate how specific neuronal sub-populations and circuit connections within the medial...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the neural substrates of context-dependent decision-making in mice. The $252,125 award, spanning from September 2024 to March 2028, will leverage whole-brain functional magnetic resonance imaging (fMRI) and optogenetic techniques to identify brain regions involved in maintaining contextual information and determine how they...