This $160,272 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a research project titled "Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia." The overarching goal is to investigate whether connectivity-guided theta burst stimulation (TBS) can alter hippocampal neural activity and cognitive function in patients with schizophrenia. The project will involve a combination...
The University of Pittsburgh was awarded a $775,706 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant, awarded on August 9, 2024, will fund a prospective study on the neural, molecular, and functional impacts of reducing anticholinergic burden in mid- to late-life patients with schizophrenia spectrum disorders. The study aims to understand the effect of anticholinergic burden reduction on cognition, quality of...
This $420,519 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research to explore the use of temporal interference (TI) electrical neurostimulation as a non-invasive method for deep brain stimulation. The project aims to characterize the effects of TI on brain activity and functional connectivity using combined TI and fMRI in human subjects (Aim 1), and then apply TI to the dorsal anterior cingulate...
The National Institute of Mental Health (NIMH) awarded a $147,656 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Beth Israel Deaconess Medical Center, Inc. in Boston, MA. The grant, with an award date of December 3, 2024 and ultimate completion date of June 9, 2026, will fund a study to develop a data-driven framework for mapping the effects of transcranial electrical stimulation on audiovisual integration and hallucinations. The research aims to determine if cathodal...
This $779,842 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to test whether the use of biomarkers can lead to better outcomes for patients experiencing a first episode of psychosis (FEP). The study will characterize 410 FEP patients using three biomarkers - a brain imaging scan and two genetic tests - to identify those likely to not respond to first-line antipsychotics but have low risk of side...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $189,540 to the University of Pittsburgh to conduct a 5-year research study on the effects of schizophrenia and cannabis use on cannabinoid CB1 receptor expression and signaling in the dorsolateral prefrontal cortex. The study aims to characterize the independent and combined impacts of schizophrenia and THC exposure on terminal type-specific CB1...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is funding a $1,217,886 multi-center clinical trial to develop a decision support tool for guiding the use of clozapine in first-episode psychosis (FEP) patients. The trial will evaluate whether a combination of three biomarkers - a functional brain scan, and genetic tests for weight gain and agranulocytosis risk - can help identify FEP patients who are...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to develop a Clozapine Decision Support Tool for patients experiencing a first episode of psychosis (FEP). The University of Alabama at Birmingham (UAB) will receive $731,452 to conduct a multi-center, randomized clinical trial to evaluate the use of three biomarkers - a resting-state fMRI scan, a genetic test for weight gain risk, and a genetic test for...
The National Institute of Mental Health (NIMH) awarded a $498,429 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Children's Research Institute in Washington, D.C. The project, titled "Identifying the Multi-Modal Factors that Determine Individual Response to tDCS," aims to apply advanced machine learning algorithms to a unique multimodal dataset of over 225 transcranial direct current stimulation (tDCS) sessions. The goal is to determine which factors, such as...
This federal Project Grant award from the National Institute of Mental Health (NIMH, CFDA 93.242 Mental Health Research Grants) provides $878,720 to the University of Pittsburgh to conduct a hybrid effectiveness-implementation randomized controlled trial. The study aims to enhance the durability of the rapid antidepressant effects of intravenous ketamine by combining it with an automated neurocognitive training intervention. The project will enroll 600 depressed outpatients receiving ketamine...