The University of Pittsburgh has been awarded a $878,720 Project Grant from the National Institute of Mental Health (NIMH) under its Mental Health Research Grants program (CFDA 93.242). The grant will fund a multi-site randomized controlled trial evaluating the effectiveness of a novel synergistic treatment approach combining intravenous ketamine infusions with a brief, automated neurocognitive training intervention. The study aims to enhance the durability of ketamine's rapid antidepressant effects by consolidating adaptive cognitive processing patterns in 600 depressed outpatients receiving ketamine treatment at clinics across the U.S. The project will assess the training's potential to extend the benefits of ketamine and identify patient characteristics that predict favorable response. It will also collect comprehensive data on the feasibility, acceptability, and costs of the combined treatment approach in real-world clinical settings. The award runs from July 2024 through May 2029.
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