Project Grant R21HL184612
- Federal Project Grant Award Summary The University of Iowa received a $248,999 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 4, 2025, with a completion date of July 31, 2028. This award supports research investigating mesenchymal cell plasticity and signaling mechanisms in lung regeneration following severe injury. The project examines how specific mesenchymal cell lineages, particularly...
- Federal Grant Award Summary The University of Iowa received a $422,075 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with completion targeted for July 31, 2027. The project deliverable is the development and prototyping of "MagniWell-12," an electromagnetic-actuated dynamic cell culture system designed as a 12-well plate insert for culturing airway epithelial cells....
- Federal Grant Award Summary The University of Iowa received a $612,186 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, with completion scheduled for May 31, 2029. The award funds basic and translational research investigating the pathophysiological mechanisms by which cardiac lysosomal dysfunction contributes to heart failure with preserved ejection fraction (HFpEF), a...
- Federal Project Grant Award Summary The University of Iowa received a $2.11 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded April 15, 2025, with a completion date of January 31, 2032. The award funds a three-project research initiative investigating genetic and molecular mechanisms of heart disease, which represents a leading cause of morbidity and mortality with heart failure alone costing...
- Federal Grant Award Summary The University of Iowa received a $651,009 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 12, 2025, with a completion date of May 31, 2029. This grant funds basic research investigating the role of junctophilin-2 (JP2) in cardiac fibroblasts and its contribution to cardiac fibrosis following myocardial infarction. The research employs advanced molecular,...
- Federal Grant Award Summary The University of Iowa received a $2.36 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 15, 2025, through March 31, 2030. This award funds a Program Project Grant (PPG) investigating the pathogenesis and therapeutic approaches for Primary Ciliary Dyskinesia (PCD), a rare genetic disorder affecting mucociliary clearance. The research program will utilize an...
- Federal Project Grant Award Summary The University of Iowa received a $713,538 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through June 30, 2029. The award funds research investigating metabolic reprogramming as a novel therapeutic approach to inhibit thrombosis and thrombo-inflammatory responses. Specifically, the research examines cytosolic malic enzyme 1 (ME1) inhibition...
- Federal Grant Award Summary The University of Cincinnati, through its Sponsored Research Services Division, received a $728,776 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 3, 2025, with a completion date of May 31, 2029. This research project investigates the dysregulation of sphingolipid metabolism and signaling in lymphangioleiomyomatosis (LAM), a rare lung disease predominantly...
- Federal Project Grant Award Summary The University of Illinois received a $760,759 project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on May 15, 2025, with completion targeted for February 28, 2029. The research will be conducted at the University of Illinois in Chicago, IL. This project grant funds basic science research investigating the immunoregulatory mechanisms of conventional dendritic cell...
- Federal Project Grant Award Summary The University of Iowa received a $765,223 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with a completion date of May 31, 2029. The award funds research investigating metabolic reprogramming mechanisms in deep vein thrombosis (DVT) and thrombus resolution. The research will examine how targeting pyruvate kinase M2 (PKM2) in platelets,...
Project Grant Summary The University of Iowa received a $233,250 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective April 1, 2026 through January 31, 2028. The award funds research investigating transforming growth factor-beta (TGF-β) signaling in the pathogenesis of lymphangioleiomyomatosis (LAM), a progressive and debilitating lung disease with limited therapeutic options. The research focuses on identifying cellular mechanisms governing functional changes among key cell populations—LAM cells, lymphatic endothelial cells, and activated LAM fibroblasts—that contribute to pulmonary dysfunction and tissue destruction characteristic of LAM. The project will deliver research products through development of novel three-dimensional organoid and lung-on-chip models designed to test the effects of TGF-β signaling on LAM nodule growth and alveolar simplification. These investigative tools and the resulting mechanistic findings are intended to identify candidate therapeutic targets and inform the development of new treatment approaches for LAM patients. The research will be conducted at the University of Iowa's Iowa City campus and represents the institution's commitment to advancing understanding of cardiovascular, pulmonary, and blood disease pathophysiology through competitive, investigator-initiated research supported by NHLBI.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $233.3k | 3/16/26 |