Project Grant R01HL178848
- This Project Grant award of $739,236.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to support research on cellular determinants of responsiveness to mTOR inhibitors in Lymphangioleiomyomatosis (LAM), a rare lung disease. The award, with a performance period from February 1, 2025 to November 30, 2028, aims to elucidate the mechanisms underlying sirolimus (an mTOR inhibitor) insensitivity in LAM patients to improve...
- Brigham & Women's Hospital Inc. received a $434,868 project grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on lipid homeostasis and mitochondrial fitness in lymphangioleiomyomatosis (LAM) pathogenesis and therapy. The award period runs from September 23, 2023 through August 31, 2024. The key products and services to be delivered under this federal grant award include: Determining the metabolic derangements...
- The University of Toledo was awarded a $579,309 Project Grant from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) on June 9, 2025. The grant supports research to investigate the role of cysteinyl leukotriene receptor signaling in regulating lung inflammation. The project aims to determine how the cysteinyl leukotriene receptor CYSLT1R promotes an inflammatory phenotype in macrophages, suppresses their proliferation, and influences the immune response...
- The University of Cincinnati was awarded a $698,432 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on "Stress Regulated RNA Degradation in Cardiac Hypertrophy." The project aims to establish the role of the UPF1 RNA helicase and the RBFOX1C RNA binding protein in regulating mRNA degradation in response to cardiac stress, and to determine the functional significance of this stress-regulated mRNA...
- This federal Project Grant award, totaling $756,875.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Cincinnati. The award supports research to investigate the fundamental mechanisms by which neutrophil extracellular traps (NETs) contribute to airway damage and infection in mucoobstructive lung diseases, such as cystic fibrosis. Key research aims include examining how NET-mediated...
- The University of Cincinnati, through its Sponsored Research Services Division, was awarded a $156,276 project grant by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on "Hematopoietic Cells and Chemokine Regulation in Abdominal Aortic Aneurysm Associated Thrombosis". The project, with a performance period from August 1, 2025 to June 30, 2027, aims to investigate the role of platelet activation and...
- This Project Grant award of $511,987.00 from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a comparative study on gene regulatory and structural mechanisms in lamin-related cardiomyopathy. The project aims to directly compare two prevailing hypotheses on the pathogenesis of lamin A/C-related dilated cardiomyopathy (LMNA-DCM) - the gene regulatory hypothesis and the structural hypothesis - to advance the mechanistic...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the mechanosensitive mechanisms underlying angiogenesis and lung regeneration. The $618,838 award to the Medical College of Wisconsin aims to investigate how mechanical stretching forces control angiogenesis during compensatory lung growth after pneumonectomy. The research will focus on the role of the focal adhesion protein paxillin in regulating...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $233,250 to the University of North Carolina at Chapel Hill (UNC-CH) to investigate the role of lipid metabolism in lung macrophage activity and phenotypes during acute lung injury. The project aims to understand how changes in lipid metabolism alter the function of lung macrophages during influenza A virus infection, which can lead to lung inflammation...
- This Project Grant award, funded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on the role of protein S-palmitoylation in TGF-beta signaling and fibrotic lung disease at Duke University. The $165,456 grant awarded on August 15, 2025 will fund a 5-year project to investigate how S-palmitoylation of the TGF-beta receptor regulates its activity and fibrotic pathways, and the potential for targeting related...
The University of Cincinnati received a $728,776 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) effective September 3, 2025 with a completion date of May 31, 2029. The grant supports research to investigate the role of sphingolipid metabolism and signaling in the lung disease lymphangioleiomyomatosis (LAM), which primarily affects young women. The research aims to elucidate the molecular mechanisms by which the TSC2 gene inactivation and estrogen promote abnormal sphingolipid-mediated cell survival, as well as evaluate the impact of pharmacologic suppression of key sphingolipid signaling pathways and estrogen receptors on lung remodeling in vivo. This work seeks to advance understanding of the fundamental disease mechanisms underlying the female predominance of LAM and develop more effective interventions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $728.8k | 9/3/25 |