Project Grant R01HL180725
- This Project Grant award, valued at $1,088,500.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Iowa. The award supports three independent research projects related to genetic and molecular mechanisms of heart disease. Project #1 aims to define microRNA (miR) targeting events and their biological relevance in the heart, as well as understand the clinical significance of single nucleotide polymorphisms (SNPs)...
- This Project Grant award of $684,937.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of the junctophilin-1 (JP1) protein in cardiac function and heart failure. The research project is being conducted at The University of Iowa, a prominent public research university with extensive experience in federal contracting and grant work. The project aims to dissect the function of JP1...
- The federal Project Grant award of $651,009 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Iowa to investigate the role of the protein junctophilin-2 (JP2) in regulating calcium signaling in cardiac fibroblasts and its impact on cardiac fibrosis. The project aims to employ advanced molecular, physiological, and biochemical techniques, along with innovative mouse models, to elucidate the specific...
- The National Heart, Lung, and Blood Institute (NHLBI), a part of the National Institutes of Health (NIH), awarded a $699,133 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of California, Los Angeles (UCLA) to conduct research on the epigenetic regulation of heart failure with preserved ejection fraction (HFPEF). The project aims to investigate the molecular insights into the actions of SGLT2 inhibitors and GLP1 agonists across the heart,...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to the University of Utah provides $745,663 to investigate the role of the IRE1 protein in regulating cardiac fibrosis, a key mechanism underlying heart failure. The research aims to elucidate how the unfolded protein response (UPR) in cardiac fibroblasts affects their activation and production of extracellular matrix proteins during the progression of both reduced and...
- The federal Project Grant award of $126,387.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at The Johns Hopkins University to investigate the role of reduced hypusination of the translation factor eIF5A in the development of heart failure with preserved ejection fraction (HFpEF). The key objectives are to test the hypothesis that decreased eIF5A hypusination impairs the translation of ubiquitin precursors and...
- This Project Grant award for $713,538 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate metabolic reprogramming as a novel therapeutic approach for thrombotic cardiovascular disease. The key objectives are to explore how inhibiting the cytosolic malic enzyme 1 (ME1) in platelets and leukocytes can reduce their hyperactivation and susceptibility to arterial thrombosis, while minimizing bleeding risk compared to...
- This federal Project Grant award of $248,999 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on mesenchymal cell plasticity and signaling in lung regeneration. The award aims to examine how specific mesenchymal cell lineages establish and maintain maladaptive epithelial regeneration after severe lung injury, such as from influenza or COVID-19. Key objectives include investigating the proliferation, plasticity, and Notch...
- This federal Project Grant award of $772,808 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the role of cardiac metabolism and glutamine production in heart failure and cardiac fibrosis. The project, led by Temple University, aims to investigate whether cardiomyocyte glutamine production plays a pivotal role in fibroblast activation and cardiac fibrosis. Key research activities include generating a cardiomyocyte-specific...
- The University of Arizona was awarded a $735,838 project grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) on July 15, 2025. The grant supports research into the role of hexokinase 1 (HK1) mitochondrial dislocation in the development of heart failure with preserved ejection fraction (HFpEF). The key objectives are to investigate how HK1 dislocation leads to increased protein O-GlcNAcylation in cardiac endothelial cells, and to assess...
The University of Iowa was awarded a $612,186 Project Grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on the role of the lysosome in heart failure with preserved ejection fraction (HFPEF). The project aims to determine the pathophysiological impact of cardiac lysosomal dysfunction in HFPEF, which accounts for half of heart failure hospitalizations in the U.S. The research will investigate how the lysosomal protein GILT protects against cardiac immuno-metabolic imbalances in obesity-associated HFPEF. The award has a start date of September 1, 2025, and is scheduled for completion by May 31, 2029. This grant supports the university's expertise in advanced cardiovascular research and its role as a critical partner for federal agencies advancing scientific knowledge and addressing national public health priorities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $612.2k | 8/28/25 |