Project Grant P01HL172740
Award Date
6/15/25
Completion Date
3/31/30
Dollars Obligated
$2.4M
Federal Agency
National Heart Lung and Blood Institute
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Iowa City, IA 52242, USA
Similar Awards
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is providing $551,863 to The University of Iowa to define the mechanism by which prostaglandin E2 (PGE2) balances absorption and secretion of airway surface liquid in the lungs. The research aims to establish new regulatory nodes between ion transport, its regulation, and physiological function, with the goal of identifying novel...
This federal Project Grant award of $2,000,987.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to examine how the antiviral immune response and associated metabolic changes in the respiratory epithelium can promote the growth of Pseudomonas aeruginosa biofilms during viral-bacterial co-infections in cystic fibrosis patients. The research, led by the Trustees of Dartmouth College, aims to elucidate the molecular mechanisms...
This $651,019 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is funding research to elucidate the mechanisms behind dysfunctional epithelial repair processes that contribute to the development of pulmonary fibrosis. The research aims to identify factors driving aberrant epithelial cell states, determine the role of HIF signaling in preventing functional alveolar repair, and investigate niche-specific mechanisms regulating...
This $5,715,866 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to develop novel, transformative therapies to substantially reduce the burden of pulmonary fibrosis (PF). The 5-year program will focus on investigating the early, pre-symptomatic progression of familial pulmonary fibrosis (FPF) to identify critical mechanisms driving disease initiation and progression. Key activities include: Analyzing...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), supports research to understand the role of alveolar epithelial cell stress signaling in the pathogenesis of pulmonary fibrosis. The award, made under the Cardiovascular Diseases Research Program (CFDA 93.837), totals $683,564 and is effective from July 1, 2025 through March 31, 2030. The research aims to elucidate how aberrant transitional alveolar type 2...
This $116,625 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will support a research study to characterize novel subtypes of abnormalities in airway and chest wall deformation in patients with Chronic Obstructive Pulmonary Disease (COPD). The study will leverage established datasets from nationwide longitudinal lung studies to investigate the associations between these airway and chest wall...
This federal Project Grant award for $123,000.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, with a period of performance from February 1, 2025 to November 30, 2026, supports research to investigate the role of the Hedgehog signaling pathway in regulating progenitor cell differentiation and its potential contribution to two major lung diseases, COPD and IPF. The funded project aims to use a...
This $762,867.00 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of the protein cofilin-1 in maintaining mitochondrial health and function within airway epithelial cells. The goal is to determine how the loss of cofilin-1 impacts mitochondrial dynamics, biogenesis, and mitophagy, and how these mitochondrial changes contribute to airway epithelial...
This federal Project Grant award of $1,297,063.94 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research focused on understanding the role of p16INK4A-expressing fibroblasts and their secretory phenotype (SASP) in promoting epithelial regeneration after injury in lung alveoli. The principal investigator will utilize an advanced mouse reporter line to isolate and characterize alveolar p16INK4A+ fibroblasts,...
This federal Project Grant award for $595,286.00, provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate a previously unappreciated mechanism of regulating collagen clearance in the lungs. The research seeks to delineate the pathways and upstream/downstream mechanisms governing a cellular homeostatic feedback loop that senses collagen synthesis and regulates its clearance. This work will use mouse...