Project Grant R21HL184316
- The National Heart, Lung, and Blood Institute awarded The Washington University $759,584 on September 1, 2026, for research developing high-density diffuse optical tomography (HD-DOT) methods for bedside neuroimaging of brain health in children undergoing extracorporeal membrane oxygenation (ECMO) support. This award is made under the Cardiovascular Diseases Research program (CFDA 93.837). The research aims to advance HD-DOT imaging to evaluate functional connectivity and cerebral oxygenation in...
- The National Heart, Lung, and Blood Institute awarded Children's Research Institute $1,818,088 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate how postnatal hypoxemia—reduced blood oxygen levels present in cyanotic congenital heart disease—impacts cardiac maturation and surgical recovery outcomes in pediatric patients. The project will examine the interaction between hypoxemia, myocardial immaturity, and postoperative complications through...
- The National Heart, Lung, and Blood Institute (NHLBI) at the Department of Health and Human Services awarded The Leland Stanford Junior University $755,271 on August 25, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop, validate, and clinically evaluate a magnetic resonance imaging method for assessing blood flow hemodynamics in pediatric and young adult congenital heart disease patients. The project will augment 4D-flow MRI capabilities to enable direct...
- The National Heart, Lung, and Blood Institute awarded The Washington University $545,304 on July 20, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research into extracellular vesicles as a prenatal rescue therapy for abnormal lung vasculature development in congenital diaphragmatic hernia. The project investigates stem cell-derived nanoparticles called extracellular vesicles that contain bioactive molecules critical for normal lung development. Preliminary...
- Federal Grant Award Summary Boston Children's Hospital received a $267,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with completion anticipated by July 31, 2027. The award funds research to identify shared molecular mechanisms underlying congenital heart disease (CHD) and neurodevelopmental delay and disability (NDD) by characterizing dysregulated gene expression in...
- The National Institute of Child Health and Human Development awarded Boston Children's Hospital $356,000 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to develop artificial intelligence models that predict neurocognitive outcomes in children with congenital heart disease by integrating clinical, surgical, genomic, and neuroimaging data. The research addresses the gap that nearly half of children and adolescents with...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $174,621 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop cardiac magnetic resonance imaging (CMR) techniques for monitoring congenital heart disease using ultra-low field (ULF) MRI systems. The recipient will adapt CMR to an inexpensive, unshielded, open-geometry ULF MRI system and apply machine learning techniques to mitigate hardware limitations and...
- The National Institutes of Health National Heart Lung and Blood Institute awarded The General Hospital Corporation (Massachusetts General Hospital) $186,840 under CFDA 93.837 Cardiovascular Diseases Research on July 3, 2026, for advanced analysis of high-resolution cardiac diffusion tensor imaging (DTI). The funded work develops and applies DTI phenomapping, a voxel-level quantitative analysis approach for cardiac magnetic resonance imaging that resolves distinct microstructural patterns in...
- The National Heart, Lung, and Blood Institute awarded Worcester Polytechnic Institute $759,243 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop personalized computational and in vitro flow models of the fetal aorta and evaluate novel hemodynamic metrics for improved prenatal diagnosis of fetal coarctation of the aorta (COA). The project addresses limitations in contemporary prenatal imaging-based screening for COA, a congenital heart defect affecting...
- The National Heart, Lung, and Blood Institute, under the Department of Health and Human Services National Institutes of Health, awarded The Washington University $768,128 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to mechanistically evaluate the role of oscillatory shear stress in deep vein thrombosis prevention. The recipient will conduct in vitro, in vivo, and human model studies to determine whether restoration of oscillatory shear stress in veins...
The National Heart, Lung, and Blood Institute awarded The Washington University $459,175 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to advance high-density diffuse optical tomography (HD-DOT) methods for perioperative neuromonitoring in children with congenital heart disease. The project develops HD-DOT technology to evaluate brain health through bedside neuroimaging of functional connectivity and cerebral oxygenation in perioperative settings. The research addresses mechanisms, timing, and factors contributing to neurological injuries in the more than 2.5 million congenital heart disease survivors in the United States, more than two-thirds of whom live with moderate to severe neurological disabilities. HD-DOT overcomes significant limitations of functional MRI by providing portable, silent bedside neuromonitoring capability. The award is designated as an Exploratory/Developmental Research Project Grant (R21) issued under Notice of Special Interest NOT-HL-24-037 and PA-25-304 to encourage early-stage innovative bioengineering projects with potential for preclinical and translational advancement. Performance of the research occurs in St. Louis, Missouri, with a period of performance from August 15, 2026, through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $459.2k | 8/4/26 |