Project Grant R01HL185766
- The National Institutes of Health National Heart, Lung, and Blood Institute awarded The Children's Hospital of Philadelphia $1,741,543 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate lung injury in pediatric hematopoietic cell transplant recipients. The research examines molecular mechanisms of pulmonary toxicity in pediatric HCT recipients, who experience lung injury in up to 40% of cases with mortality rates of 40% when requiring...
- The National Heart, Lung, and Blood Institute awarded The Trustees of Columbia University in the City of New York $1,151,498 on March 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research on lung epithelial development and regeneration. The research aims to restore epithelial integrity and prevent end-stage lung diseases such as idiopathic pulmonary fibrosis by understanding how the lung epithelium develops in embryos and regenerates following injury....
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $917,304 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate cellular and molecular coordination of alveolar regeneration. The award supports research into how epithelial, endothelial, and mesenchymal cells coordinate repair of alveolar structures damaged by infection, environmental toxins, hyperoxia, or barotrauma. The project examines...
- The National Institute of Child Health and Human Development awarded Massachusetts General Hospital $466,740 on August 3, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate congenital diaphragmatic hernia (CDH) using fetal tracheal aspirates as a molecular and cellular window into hypoplastic lung development. The project will examine when an inflammatory signature—characterized by increased cytokeratin 5 and activated NFKB expression with...
- The National Heart, Lung, and Blood Institute awarded The Washington University $1.902 million on June 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to define and correct immune-epithelial pathways underlying chronic muco-obstructive lung disease triggered by viral infection, allergen, smoke, or pollution exposure. The research identifies and characterizes a distinct subset of basal epithelial stem cells (basal-ESCs) that drive muco-obstructive disease phenotypes...
- The National Institutes of Health National Heart Lung and Blood Institute awarded The Washington University $635,247 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of resolution-phase neutrophils in acute respiratory distress syndrome (ARDS) recovery. The project tests the hypothesis that neutrophils activate counter-regulatory mechanisms, including expression of 15-lipoxygenase (15-LO), in lung tissue following acute injury to...
- The National Heart, Lung, and Blood Institute awarded the University of Southern California $1,263,067 on September 10, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate transitional alveolar epithelial cells in normal lung development. The research, led by Principal Investigator Parviz Minoo, examines intermediate and transitional alveolar epithelial cells (AEC) in neonatal lungs undergoing alveologenesis, with particular focus on their regenerative...
- The National Heart, Lung, and Blood Institute awarded The Washington University $459,175 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to advance high-density diffuse optical tomography (HD-DOT) methods for perioperative neuromonitoring in children with congenital heart disease. The project develops HD-DOT technology to evaluate brain health through bedside neuroimaging of functional connectivity and cerebral oxygenation in perioperative settings. The...
- The National Heart, Lung, and Blood Institute awarded The Washington University $764,681 under the Cardiovascular Diseases Research program (CFDA 93.837) on May 1, 2026, to conduct research into a multipotent fibroblast population and platelet-derived growth factor receptor beta–dependent immuno-fibrotic responses in heart failure. The research addresses cardiac fibrosis and left ventricular dysfunction in heart failure by investigating a novel population of stem cell antigen-1–expressing,...
- The National Heart, Lung, and Blood Institute awarded The Trustees Of The University Of Pennsylvania $1,624,110 on June 25, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate mechanisms of lung repair and regeneration following acute injury. The project examines dysplastic versus euplastic repair pathways in lung tissue. The research addresses how basal stem cells migrate into the alveolar niche after injury, displacing AT2 progenitor cells and creating an...
The National Heart, Lung, and Blood Institute awarded The Washington University $545,304 on July 20, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research into extracellular vesicles as a prenatal rescue therapy for abnormal lung vasculature development in congenital diaphragmatic hernia. The project investigates stem cell-derived nanoparticles called extracellular vesicles that contain bioactive molecules critical for normal lung development. Preliminary experimental studies using congenital diaphragmatic hernia models demonstrated that prenatal extracellular vesicle treatment improves lung vascular formation. This project will determine the mechanisms by which extracellular vesicles reverse fetal lung vascular remodeling and identify which infants with severe disease are most likely to benefit. Work includes studying how extracellular vesicles promote lung endothelial cell regeneration and employing spatial transcriptomics and proteomics to identify the molecular pathways modulated by treatment. The award funds research performed at The Washington University's Office of Sponsored Research Services in St. Louis, Missouri, with a period of performance from July 20, 2026, through March 31, 2031. This project grant addresses an urgent clinical need: approximately one-third of infants born with congenital diaphragmatic hernia die primarily due to abnormal development of lung blood vessels and elevated blood pressure after birth, and current postnatal surgical repair of the diaphragmatic defect cannot reverse prenatal lung damage.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $545.3k | 7/22/26 |