Federal Project Grant Award Summary

Massachusetts General Hospital received a $266,541 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 1, 2026 through April 30, 2028. The grant funds research to quantify longitudinal changes in sleep electroencephalographic (EEG) signals and their relationship to daytime cognitive function and alertness. The research leverages existing data collected from highly controlled inpatient protocols involving well-phenotyped participants exposed to various sleep conditions, including extended sleep, sleep restriction, circadian misalignment, and pharmacological interventions (caffeine, modafinil, and melatonin). All protocols included comprehensive sleep recordings, objective performance testing, subjective mood and alertness assessments, and self-reported sleep quality measures.

The project delivers quantitative analysis of trait versus state variations in sleep EEG signals, night-to-night variability patterns, and the dependence of EEG characteristics on modifiable behavioral factors and individual characteristics such as age. These research products address critical gaps in understanding normal sleep physiology and establishing baseline parameters necessary to reduce false positive and false negative conclusions in clinical and research applications of EEG-based monitoring and machine learning analyses. The research is conducted at Massachusetts General Hospital's Research Management Division in Boston, Massachusetts.