Project Grant R21HL181694
- This federal Project Grant award, totaling $1,621,874.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) with an award date of Sep 23, 2025 and an ultimate completion date of Jun 30, 2027. The award was granted to Brigham & Women's Hospital Inc., a subsidiary of the larger Partners Healthcare System (now Mass General Brigham), to conduct research on the role of ambient lighting in circadian misalignment and its...
- This Project Grant award for $730,993.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms by which internal circadian misalignment contributes to the cardiometabolic risk associated with sleep loss. The project aims to determine if preventing light exposure and food intake during the circadian biological night can mitigate the adverse cardiometabolic effects of insufficient sleep. Researchers at...
- This $691,124.00 project grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on the relationship between circadian disruption and cardiometabolic risk during the transition from adolescence to young adulthood. The project aims to test the hypothesis that persistent circadian disruption, including misaligned sleep, eating, and activity timing, will be related to the development of cardiometabolic risk through epigenetic...
- This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), will fund research to investigate place-based factors contributing to sleep health disparities in the United States. The $177,385 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, will: 1) Estimate sleep health measures and environmental circadian misalignment across different populations and geographies; 2) Examine...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $217,281 to Texas A&M University to develop statistical and computational tools to analyze rhythmic gene expressions for a deeper understanding of circadian rhythms. The project aims to address key scientific questions around how the rhythmicity of genes is influenced by genotypes, feeding types, and drugs. Specifically, the work will focus on identifying...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $385,033 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Oakwood University, Inc. in Alabama. The grant will fund research to investigate how circadian rhythm disruptions, such as from fragmented day-night cycles, impact sleep patterns and binge-like eating behavior in mice. The project aims to examine the neurological mechanisms underlying how the brain responds to changes in light-dark cycles...
- This Project Grant award of $790,584.00 from the National Heart, Lung, and Blood Institute (CFDA Program 93.837 - Cardiovascular Diseases Research) supports research to determine the optimal duration of overnight naps that restore normal blood pressure patterns and minimize performance impairment among night shift workers. The study, conducted by the University of Pittsburgh, aims to address the disproportionate cardiovascular disease risk faced by night shift workers in public safety and...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $763,858 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System Inc.) to assess the impact of improving cardiovascular disease (CVD) care for adults with diagnosed diabetes across diverse global settings. The project, led by Dr. Jennifer Manne-Goehler and an interdisciplinary team, aims to develop the PREDICT-DM global...
- This federal Project Grant award for $743,388, awarded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on the mechanisms by which sleep loss and circadian misalignment contribute to insulin resistance and the development of Type 2 diabetes mellitus. The award will fund two randomized controlled trials with 48 adult participants to characterize the role of cortisol rhythms and downstream metabolomic and endocrine...
- This $147,486 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Southern California to investigate the heterogeneous intercellular signaling of hematopoietic stem and progenitor cells (HSPCs) and its changes around the circadian clock. The research aims to advance understanding of how HSPC cell-cell communication and gene expression patterns within the bone marrow microenvironment are...
This $281,560 Project Grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The funding supports mathematical modeling research to investigate peripheral metabolic circadian rhythms and their implications for managing shift work and jet lag. The project aims to develop and validate models for peripheral circadian rhythms, which may underlie short-term gastrointestinal symptoms and longer-term cardiometabolic disease risks associated with disruption of these rhythms. The research focuses on identifying meal timing as a key synchronizer of peripheral circadian rhythms, including those of circulating serum lipids. The 2-year project will be conducted by researchers at Brigham & Women's Hospital, a subsidiary of the larger Partners Healthcare System.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $281.6k | 8/25/25 |