Federal Project Grant Award Summary

The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Johns Hopkins University for the development of cardiac organoids with deliberate cellular heterogeneity to model sinus node dysfunction (SND). The award, effective April 1, 2026 through March 31, 2028, supports research aimed at creating human cardiac pacemaker organoids derived from induced pluripotent stem cells (iPSCs) that accurately replicate the structure and dysfunction of the sinoatrial node. The project will integrate nonmyocytes into these organoids and apply mechanical strain stimulation to simulate disease environments, enabling rigorous investigation of SND mechanisms and identification of molecular targets for novel therapeutic interventions.

The ultimate deliverable is an advanced disease modeling platform that replicates the cellular diversity of the native sinoatrial node, with the objective of reducing reliance on permanent pacemaker implantation and improving patient outcomes for individuals with SND—a significant heart rhythm disorder affecting both pediatric and adult populations. This research addresses a critical gap in translational science by providing a reliable human model system to elucidate the underlying causes and progression of SND, which currently lacks adequate preclinical platforms for therapeutic development. Note: The obligated funding amount displays as $0.00, which may reflect pending financial processing or administrative status of the award.