This $764,659 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports research to investigate the mechanisms underlying neuropathic spontaneous pain. The key objectives are to characterize the role of local vascular movement in triggering neuropathic spontaneous pain, determine how mechanoreceptors in sensory neurons contribute...
This $594,956 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to determine the mechanisms responsible for transducing esophageal stretch into activation of vagal afferent nerves. The research aims to identify the mechanosensitive receptors, such as Piezo channels, and voltage-gated sodium channels required for action potential...
This federal Project Grant award, with the ID R35NS132231, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $885,128 grant supports research aimed at gaining a molecular-level understanding of the design principles governing somatosensation and nociception by membrane sensory receptor channels, as well as broader contextualization. The research, led...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) will provide $249,000.00 to the University of Wisconsin - Madison to support research led by Dr. Nicholas Burgraff. The research aims to unravel the mechanisms of opioid-induced airway constriction, with the goal of developing novel therapeutic strategies to improve patient safety and outcomes in medical scenarios where opioids are...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $350,000 to the University of California, Davis to conduct research on the neuroimmune control of lung inflammation. The key objectives of this research project are to determine the role of vagal afferent neurons and the associated neuro-immune circuitry in regulating lung inflammation induced by viral pathogens. The...
This federal Project Grant award, totaling $1,612,516.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant, awarded on August 1, 2024, supports research at the University of Illinois focused on investigating the role of nicotinic acetylcholine receptors in neuropathic pain. The project aims to advance scientific understanding of the neural...
This $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of Schwann cell PIEZO1 in pain sensation. The key objectives are to: 1) develop and validate adeno-associated virus (AAV) vectors for selective inhibition of Schwann cell PIEZO1, and 2) determine the sensory effects of Schwann cell...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $114,594 to the University of Virginia to investigate the role of the neuropeptide PACAP in protecting neonatal respiratory function. The research aims to: 1) determine if PACAP is necessary for establishing and protecting stable respiratory rhythmogenesis in neonates, especially in response to thermal stress and CO2 changes,...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $522,794 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Illinois to study the role of the voltage-gated proton channel HV1 in the development of pulmonary hypertension. The research aims to elucidate the molecular mechanisms by which HV1 regulates the progression of pulmonary hypertension and evaluate the potential of HV1 blockers as a treatment approach. This 4-year grant, with an award date...