Project Grant R01HL181356
- This federal Project Grant award, valued at $180,174 and awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), aims to develop a framework for designing the next generation of pediatric ARDS (Acute Respiratory Distress Syndrome) clinical trials. The key products and services to be delivered under this 5-year grant include: Comparing heterogeneity of treatment effect (HTE) analysis methodologies in a trial of pediatric ARDS ventilator management....
- This federal Project Grant award, issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $866,579 to The Children's Hospital of Philadelphia Research Institute to conduct an adaptive, parallel-stepped-wedge hybrid cluster-randomized trial. The trial aims to determine if an "Optimizing Ventilation (OPTI-VENT) Bundle" can improve cardiac arrest...
- This federal Project Grant award of $685,724 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support a multi-center observational study to measure ventilation during out-of-hospital cardiac arrest resuscitation. The study aims to facilitate clinical trial design by analyzing ventilation metrics using data from a large cardiac arrest database. The awardee, The University of Texas Southwestern Medical Center, will leverage a novel method for...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $178,846 Project Grant under CFDA 93.837 - Cardiovascular Diseases Research to the University of California, San Diego (UC San Diego) for a 5-year period from August 1, 2025 to July 31, 2030. The grant will fund a research project titled "Optimal Ventilator Management in Patients with ARDS on ECMO" to investigate personalized positive end-expiratory pressure (PEEP) adjustment guided by esophageal manometry to minimize...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a randomized clinical trial to evaluate the use of personalized oxygen therapy targets for improving mortality outcomes among mechanically ventilated critically ill adults. The $874,997 award, effective September 15, 2025 through August 31, 2026, will fund research conducted by the Vanderbilt University Medical Center to validate a statistical model for...
- This federal Project Grant award of $305,218 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development of ASSURANCEET, a novel pediatric endotracheal tube (ETT) designed to improve airway management and patient safety. The product aims to replace the error-prone inflatable balloon in traditional ETTs with ultra-soft micro-baffles that gently seal the airway while exerting less force. Preliminary testing...
- The federal Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), focuses on investigating the role of the transcription factor MEOX2 in regulating the function of alveolar matrix fibroblasts and their impact on alveolar development and vascular formation. The $721,826 award to Children's Hospital Medical Center in Cincinnati, Ohio aims to elucidate the molecular mechanisms by which MEOX2 governs the...
- This federal Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), to support research on improving outcomes for pediatric in-hospital cardiac arrest. The $279,644 grant was awarded to The Children's Hospital Corporation, doing business as Boston Children's Hospital, to develop a novel outcome measure called "time to return of spontaneous circulation (ROSC)" for use in clinical...
- This federal Project Grant award of $224,083 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865, the Child Health and Human Development Extramural Research program, supports research on the use of oscillometry for evaluating pulmonary function in children following acute respiratory failure. The project aims to advance understanding of the long-term impacts of acute respiratory conditions, such as pneumonia and asthma, on...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $748,970 to The Trustees of the University of Pennsylvania to better understand how contextual factors and intervention features influence care delivery for patients undergoing invasive mechanical ventilation. The project aims to quantify penetration of four evidence-based treatments over time, develop a conceptual model of ICU implementation, and use...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $816,119 to Oregon Health & Science University (OHSU) for the "Pediatric Prehospital Ventilation Trial (PEDI-VENT)" project. The overall objective is to conduct an in-depth analysis of pediatric prehospital emergency ventilation and identify the best ventilation strategies to improve patient outcomes. The project will leverage the infrastructure of the NHLBI-funded PEDI-PART trial to collect and analyze physiological data from EMS agencies, applying advanced signal processing to determine optimal ventilation rates for critically ill children treated in the emergency medical services system. This observational study aims to inform prehospital ventilation guidelines and practices to enhance respiratory care and patient outcomes for pediatric emergency cases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $816.1k | 9/19/25 |