This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $793,956.00 to Resuscitation Innovations LLC (dba Advancedcpr Solutions LLC) to develop and evaluate a novel approach for improving survival rates among patients experiencing refractory cardiac arrest. The project aims to advance the use of "head-up CPR and aortic occlusion" as an intervention to increase the chances of...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $889,188 to develop a new intravenous oxygen therapy for early resuscitation of cardiac arrest patients. The project aims to optimize a gas carrier technology based on pH-responsive polymeric microbubbles that can safely deliver high volumes of oxygen without requiring ventilation, with the goal of rapidly restoring oxygen levels and...
This $140,329 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research evaluating racial and ethnic disparities in patient outcomes and intra-arrest resuscitation practices for in-hospital cardiac arrest (IHCA). The key objectives are to: 1) Examine racial and ethnic disparities in time to return of spontaneous circulation (ROSC), survival to hospital discharge, and favorable functional...
This $167,383 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research by Dr. Ethan Abbott at the Icahn School of Medicine at Mount Sinai to improve survival and clinical outcomes for patients experiencing out-of-hospital cardiac arrest (OHCA). The key objectives are to: 1) develop a baseline predictive model to identify pre-hospital, patient-level, and hospital-level factors...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $752,495 to the University of Connecticut to develop a deep learning-based method for removing cardiopulmonary resuscitation (CPR) artifacts from electrocardiogram (ECG) signals. The goal is to enable continuous CPR delivery during automated external defibrillator (AED) use, while maintaining accurate cardiac rhythm analysis and shock...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $2,428,701 to the University of Missouri at Kansas City (UMKC) to conduct a prospective, multi-site study of 1,000 pregnant individuals with cardiovascular disease. The study aims to identify patient characteristics and structural care factors associated with adverse pregnancy outcomes, maternal cardiovascular events, and...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 Cardiovascular Diseases Research, provides $402,117 to the University of North Carolina at Chapel Hill. The award will support the adaptation and pilot testing of a family-centered intervention, SUCCEED-ICU, designed to improve long-term outcomes for survivors of acute respiratory failure. The project aims to: 1) adapt the existing SUCCEED intervention for use in acute respiratory...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $498,991.40 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Arkansas. The grant, effective January 2, 2025 through December 31, 2027, will support the development of microphysiological systems to investigate molecular pathways and cardiomyocyte function in response to hypoxic cardiac injury associated with myocardial infarction and ischemia-reperfusion injury. The project aims to...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,088,500.00 in funding to The University of Iowa from April 15, 2025 to January 31, 2032. The grant supports three independent research projects focused on: 1) defining microRNA targeting events and their biological relevance in the heart, and understanding the clinical significance of SNPs that alter cardiovascular microRNA...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 "Cardiovascular Diseases Research" will provide $126,059 from September 1, 2024 to August 31, 2029 to the University of Colorado-Denver. The project aims to use proteomics and metabolomics approaches to study the systems biology of acute and chronic multi-organ failure in children with congenital heart disease (CHD). Specifically, the project will measure changes in the circulating...