Project Grant R21HL181700
- This $691,124.00 project grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on the relationship between circadian disruption and cardiometabolic risk during the transition from adolescence to young adulthood. The project aims to test the hypothesis that persistent circadian disruption, including misaligned sleep, eating, and activity timing, will be related to the development of cardiometabolic risk through epigenetic...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $392,812.00 to Texas A&M University to conduct research on the effects of circadian rhythm disruption on the mammary microenvironment. The researchers will leverage spatial transcriptomics and Bayesian modeling approaches to investigate how disruptions to the body's 24-hour cycle impact cellular activities and...
- This $281,560 Project Grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The funding supports mathematical modeling research to investigate peripheral metabolic circadian rhythms and their implications for managing shift work and jet lag. The project aims to develop and validate models for peripheral circadian rhythms, which may underlie short-term gastrointestinal symptoms and longer-term...
- This $147,486 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Southern California to investigate the heterogeneous intercellular signaling of hematopoietic stem and progenitor cells (HSPCs) and its changes around the circadian clock. The research aims to advance understanding of how HSPC cell-cell communication and gene expression patterns within the bone marrow microenvironment are...
- This Project Grant award for $730,993.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms by which internal circadian misalignment contributes to the cardiometabolic risk associated with sleep loss. The project aims to determine if preventing light exposure and food intake during the circadian biological night can mitigate the adverse cardiometabolic effects of insufficient sleep. Researchers at...
- This $380,089.00 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research on the molecular mechanisms underlying circadian rhythms. The project aims to determine the mechanisms that define the period and light-dependent phase shift of circadian rhythms, which are critical for aligning cellular and physiological processes with external environments. By...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $134,982 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the genetic and nutritional control of sleep across seasons. The overarching goal is to investigate how the circadian clock and seasonal variations in light and nutrients impact sleep and feeding behaviors. Key activities include analyzing sleep, feeding,...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program provides $143,829 to The University of Kentucky Research Foundation to study the circadian regulation of cardiomyocyte size and function. The primary objectives are to establish human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as a model for investigating how the intrinsic cardiomyocyte circadian clock impacts cell size...
- This federal Project Grant award, valued at $755,257.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award aims to study the role of GPI-anchor biosynthesis in regulating sleep, with the goal of improving understanding of the genetic factors underlying sleep disorders such as insomnia. The research will be conducted by Texas A&M University and will involve a multi-pronged approach, including...
- The University of Alabama at Birmingham (UAB) was awarded a $539,342 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the circadian mechanisms governing cardiac growth. The project aims to investigate how the cardiomyocyte circadian clock regulates cardiac processes, particularly the branched chain amino acid catabolism and mTOR activation during the active and sleep periods. This research seeks to advance...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $217,281 to Texas A&M University to develop statistical and computational tools to analyze rhythmic gene expressions for a deeper understanding of circadian rhythms. The project aims to address key scientific questions around how the rhythmicity of genes is influenced by genotypes, feeding types, and drugs. Specifically, the work will focus on identifying differentially rhythmic genes, clustering these genes, and mapping gene networks to reveal salient features of rhythmic gene expression. This research is expected to benefit circadian research, understanding cardiovascular diseases associated with circadian rhythm disruption, and drug development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $217.3k | 9/16/25 |