Project Grant K99HL177253
- This Project Grant award for $730,993.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms by which internal circadian misalignment contributes to the cardiometabolic risk associated with sleep loss. The project aims to determine if preventing light exposure and food intake during the circadian biological night can mitigate the adverse cardiometabolic effects of insufficient sleep. Researchers at...
- This $691,124.00 project grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on the relationship between circadian disruption and cardiometabolic risk during the transition from adolescence to young adulthood. The project aims to test the hypothesis that persistent circadian disruption, including misaligned sleep, eating, and activity timing, will be related to the development of cardiometabolic risk through epigenetic...
- This federal Project Grant award, valued at $755,257.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award aims to study the role of GPI-anchor biosynthesis in regulating sleep, with the goal of improving understanding of the genetic factors underlying sleep disorders such as insomnia. The research will be conducted by Texas A&M University and will involve a multi-pronged approach, including...
- This federal Project Grant award for $743,388, awarded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on the mechanisms by which sleep loss and circadian misalignment contribute to insulin resistance and the development of Type 2 diabetes mellitus. The award will fund two randomized controlled trials with 48 adult participants to characterize the role of cortisol rhythms and downstream metabolomic and endocrine...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $385,033 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Oakwood University, Inc. in Alabama. The grant will fund research to investigate how circadian rhythm disruptions, such as from fragmented day-night cycles, impact sleep patterns and binge-like eating behavior in mice. The project aims to examine the neurological mechanisms underlying how the brain responds to changes in light-dark cycles...
- This $673,512 Project Grant awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research by the University of California, San Francisco (UCSF) to investigate the neural mechanisms underlying breathing rhythms. The project aims to determine whether the subconscious breathing rhythm arises from an autonomous oscillator or reciprocal inhibition between key neuronal populations in the brainstem. UCSF will use advanced mouse...
- This federal Project Grant award, provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports a comprehensive sleep neuroimaging study to investigate the role of local sleep disturbance in obesity risk. The $568,125 award to Brigham Young University, with a period of performance from September 2025 to August 2028, will utilize advanced functional neuroimaging and polysomnographic methods to elucidate the underlying mechanisms linking poor...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $594,547 to Harvard Medical School to conduct research on the regulation of arousal and sleep quality. The project aims to characterize a gut-to-brain signaling pathway that uses information about ingested nutrients to control arousal levels and sleep depth, without affecting overall sleep duration. The research will investigate...
- This federal Project Grant award for $696,470, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the relationship between prenatal maternal sleep and cardiovascular disease risk in offspring. The University of Denver is the primary awardee, and they have sub-awards with Northwestern University and the University of Colorado, Anschutz Medical Center. The key objectives are to: 1) examine how prenatal maternal sleep...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $217,281 to Texas A&M University to develop statistical and computational tools to analyze rhythmic gene expressions for a deeper understanding of circadian rhythms. The project aims to address key scientific questions around how the rhythmicity of genes is influenced by genotypes, feeding types, and drugs. Specifically, the work will focus on identifying...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $134,982 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the genetic and nutritional control of sleep across seasons. The overarching goal is to investigate how the circadian clock and seasonal variations in light and nutrients impact sleep and feeding behaviors. Key activities include analyzing sleep, feeding, energetic, and hypothalamic signaling defects in mouse models to understand the mechanisms behind seasonal sleep and feeding adaptations. The award period runs from September 5, 2025 through June 30, 2027. This research aims to provide insights into how modern environmental factors such as year-round access to food and electronic light exposure may disrupt natural seasonal sleep-wake cycles and contribute to the development of obesity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $135.0k | 9/3/25 |