Project Grant R01HL180477
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at Baylor College of Medicine to investigate the molecular mechanisms driving postoperative atrial fibrillation (POAF). The $148,296 award, made on January 31, 2025, will fund a study to identify how macrophage-mediated interleukin-6 (IL-6) signaling leads to ryanodine receptor 2 (RyR2) calcium leak in POAF. The researchers have developed a...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $673,598 to Baylor College of Medicine to conduct research on the role of cardiomyocyte-fibroblast signaling in atrial fibrillation (AF). The goal is to investigate how reduced production of the paracrine signaling molecule calcitonin, miR-31-dependent downregulation of the calcitonin receptor, and activated BMP1 signaling promote atrial remodeling, fibrosis, and AF...
- This Project Grant award of $715,180 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to understand the epigenetic regulation of trained immunity in thoracic aortic aneurysms and dissections. The objective is to determine how monocytes/macrophages in the aortic wall are trained to exhibit a pro-inflammatory phenotype, with the goal of identifying key pathways driving this process. The research will be conducted by Baylor...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $733,999 to the University of South Florida to investigate the relationship between atrial microvascular/endothelial dysfunction and the development of postoperative atrial fibrillation (POAF). The key objectives are to: 1) Evaluate microvascular signaling pathways responsible for myogenic/vasomotor/endothelial dysfunction of the atrial microvasculature in POAF...
- This Project Grant award, in the amount of $746,800.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at Baylor College of Medicine to investigate the major signaling mechanism controlling spontaneous cardiomyocyte (heart cell) proliferation in the neonatal stage. The research aims to elucidate the role of the CD36 receptor in regulating heart cell regeneration, with a...
- This federal Project Grant award, totaling $249,000.00, was provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Texas Southwestern Medical Center in Dallas, TX. The grant supports research to better understand the molecular determinants of atrial fibrillation (AF), a common and serious heart rhythm disorder. The research aims to investigate how the transcription factor TBX5 and the chromatin remodeling protein CHD4...
- This $651,967 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to elucidate the role of cardiac tissue-resident macrophages in heart failure progression. The principal investigator at the Texas Heart Institute will conduct research over a 5-year period from August 2025 to May 2030 to determine how macrophage senescence contributes to cardiomyocyte dysfunction, inflammation, and impaired clearance of cellular debris in...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $811,885 in funding to the J. David Gladstone Institutes in California to conduct research on epigenomic mechanisms of cardiac fibrosis and heart failure. The project aims to investigate the role of the MEOX1 gene as a key transcriptional regulator of fibroblast activation, fibrosis, and heart failure pathogenesis. The research leverages novel genetic mouse...
- This federal Project Grant award for $769,761 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into the mechanisms by which obesity leads to atrial fibrillation. The awardee, Weill Medical College of Cornell University, is developing a mouse model of obesity-induced atrial fibrillation to investigate how nicotinamide adenine dinucleotide (NAD+) pathways and the ATF6 endoplasmic reticulum stress pathway...
- The National Institutes of Health's National Heart, Lung, and Blood Institute awarded a $464,502 project grant to Tarleton State University under the Cardiovascular Diseases Research program (CFDA 93.837). The grant, awarded on September 1, 2025, will fund the development of an interactive computer model of the left atrium's electrophysiology to study the underlying mechanisms leading to atrial fibrillation. Key objectives include: 1) constructing an anatomically accurate 3D model of the left...
This federal Project Grant award, valued at $752,618, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Baylor College of Medicine. The grant supports a research project focused on understanding the role of inflammation in postoperative atrial fibrillation (POAF), a common complication of cardiothoracic surgery. The research aims to investigate the molecular drivers of POAF, including the involvement of infiltrating macrophages, proinflammatory cytokines like IL-6 and MIF, and their impact on atrial cardiomyocytes and fibroblasts. The project leverages a novel mouse model of POAF developed by the researchers and employs single-cell RNA sequencing to analyze changes in cell types and signaling pathways. The award began on September 2, 2025 and is scheduled for completion on May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $752.6k | 9/1/25 |