This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $720,676 to the University of Pittsburgh to develop a novel treatment strategy for myocardial infarction. The key focus is on using ultrasound-targeted microbubble cavitation (UTMC) to deliver nitro-fatty acid-based microbubbles (NFABs) to sites of microvascular obstruction and myocardial fibrosis. This approach aims to enhance perfusion,...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $295,892 to Asclepia Technology LLC to conduct a proof-of-concept study on a targeted cellular therapy for treating atherosclerotic vascular disease in minority patients. The funding will support the development and evaluation of dual-functional, echogenic immunoliposomes (DF-ELIP) that can deliver vascular stem cells (VSC) to...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $369,178 to the University of Pittsburgh to perform preclinical optimization and manufacturability testing of an immunoregulatory tissue-engineered vascular graft (TEVG) device. The key objectives are to: 1) Evaluate the in vitro performance of a silk scaffold TEVG construct seeded with extracellular vesicles (EVs); 2) Conduct...
The federal Project Grant award R56HL173809 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support the development of a novel high-speed 4D echocardiography system with adjustable multi-planar acquisition capabilities. This $677,635 award to the University of Southern California will enable the creation of advanced broadband echocardiography transducers and beamforming methods to provide higher volume acquisition rates and customizable...
This $761,042 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Pittsburgh to investigate the mechanisms driving medial arterial calcification (MAC) in peripheral artery disease (PAD). The key objectives are to: Define how the DNA damage response suppresses levels of the CD73 enzyme, which normally produces the anti-calcification molecule adenosine. Determine how reduced adenosine...
This federal Project Grant award, provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), funds research and development of an ultrasound-based technology to induce neovascularization and enhance local tissue perfusion. The $1,518,816 award, with a project period from May 15, 2024 to April 30, 2028, supports the advancement of acoustic patterning...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Program (CFDA 93.837), supports research to develop an improved bioprosthetic aortic valve using the pulmonary visceral pleura (PVP) as the base material. The total funding amount is $742,323, with a performance period from December 2024 to November 2028. The key objectives are to evaluate the mechanical, hemodynamic, and long-term durability performance of...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $134,151 to the University of California, Irvine to develop novel metasurface optical guidewires for therapeutic applications to treat previously untreatable highly stenotic coronary artery calcification (CAC) lesions. The objective is to design, develop, and manufacture metasurface optical guidewires that can provide precise...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), supports a $2,070,048 research program focused on understanding the cellular and molecular mechanisms of atherosclerosis, a leading cause of cardiovascular disease (CVD). The overarching goal is to examine how inflammation and macrophage efferocytosis (clearance of dead cells) regulate plaque stability, with the aim of developing novel CVD treatments....
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop a flexible piezo film intravascular ultrasound (IVUS) array system that can be integrated onto guidewires and catheters for coronary and peripheral interventions. The $366,006 award to Georgia Tech Research Corp will fund the exploration and demonstration of...