This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will fund a $233,250 research study at the University of Iowa to characterize novel subtypes of abnormalities in multi-volume airway and chest wall deformation in chronic obstructive pulmonary disease (COPD). The study will leverage established datasets from nationwide longitudinal lung studies to investigate the associations between these mechanical changes, COPD...
This $2,369,201 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will develop a population-based data infrastructure to evaluate the impact of non-COPD medications on outcomes for patients with chronic obstructive pulmonary disease (COPD). The project will leverage claims data covering commercially insured and Medicare populations, as well as electronic health records from the COPDGene cohort, to analyze the comparative...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), will support research into post-transcriptional regulatory networks in chronic obstructive pulmonary disease (COPD). The $708,063 award, spanning May 2025 to February 2030, will enable the University of Virginia to develop methods for identifying RNA-binding protein (RBP) regulatory networks, functionally characterize COPD-associated RBP subnetworks, and use...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will fund a $116,625 study at The University of Iowa from February 1, 2025 to January 31, 2027. The study aims to characterize clinically relevant osteoporosis and sarcopenia phenotypes in patients with chronic obstructive pulmonary disease (COPD) using advanced artificial intelligence and imaging analysis techniques. Key objectives include developing normative models of...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,052,276 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Lasarrus Clinic And Research Center Inc. The funding supports a 2-phase SBIR Fast-Track project to develop and validate a wearable multimodal sensor system for remote monitoring of chronic obstructive pulmonary disease (COPD) patients. The project aims to extend the awardee's patented "WearMe" platform to capture bilateral...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $268,500.00 to Brigham & Women's Hospital Inc. from February 1, 2025 to January 31, 2027. The project aims to develop and validate a quantitative marker of pulmonary microvascular injury using an AI-based algorithm to assess vascular perfusion from single energy non-contrast CT scans. This marker will be used to investigate the relationship between pulmonary...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $394,200 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to Weill Medical College of Cornell University. The grant supports the development and pilot testing of the COPDHEART intervention, a multicomponent behavioral program tailored to improve cardiovascular health among Black adults with chronic obstructive pulmonary disease (COPD). The project aims to identify barriers, refine the intervention...
This Project Grant award, valued at $131,783, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research (CFDA 93.837) program. The award supports a 5-year study led by Brigham & Women's Hospital to identify blood and bronchoalveolar lavage fluid biomarkers for chronic obstructive pulmonary disease (COPD) phenotypes and acute exacerbations. Key activities include developing a protocol for biospecimen collection before and after bronchoscopic lung...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated, provides $812,189.00 to conduct research on using CT imaging to screen for and subtype pulmonary hypertension in patients with chronic obstructive pulmonary disease (COPD). The 4-year project aims to identify CT imaging features that can predict the presence of pulmonary...
This $651,019 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is funding research to elucidate the mechanisms behind dysfunctional epithelial repair processes that contribute to the development of pulmonary fibrosis. The research aims to identify factors driving aberrant epithelial cell states, determine the role of HIF signaling in preventing functional alveolar repair, and investigate niche-specific mechanisms regulating...