Project Grant R21HL175625
- This federal Project Grant award of $430,606 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to create a new Pediatric Cardiorespiratory Research Training Program at Vanderbilt University Medical Center (VUMC). The goal is to provide 2-3 years of highly rigorous research training for pediatrics fellows and PhD scientists to facilitate their transition to tenure-track faculty positions as clinician-scientists. The program will support up to 2...
- The federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides funding of $158,544 to Vanderbilt University Medical Center (VUMC) from August 1, 2025 to July 31, 2030. The project aims to advance the understanding of clonal hematopoiesis of indeterminate potential (CHIP) and its role in the development of atherosclerotic cardiovascular disease (ASCVD). Specifically, the grant will (1) identify...
- This federal Project Grant award of $159,624.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Vanderbilt University Medical Center (VUMC) to investigate the role of hypoxia-inducible factor (HIF) in promoting alveolar regeneration and functional lung repair for patients with idiopathic pulmonary fibrosis (IPF) and other chronic lung diseases. The research aims to explore how modulating upstream disease mechanisms,...
- This Project Grant award for $879,567.00, funded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on lung injury in pediatric hematopoietic cell transplant (HCT) recipients. The research team at The Children's Hospital of Philadelphia (CHOP) will conduct a comprehensive characterization of the clinical, proteomic, and cell-free DNA biomarker profiles associated with the development of lung injury after HCT in...
- This federal Project Grant award of $738,154 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to develop a novel mortality risk prediction model to accurately assess mortality risk for ICU patients across all patient groups. The key objectives are to: (1) identify mechanisms of systematic measurement error in commonly used ICU mortality risk prediction models, and (2) develop an accurate ICU mortality risk prediction model. The project will...
- This federal Project Grant award of $193,984 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the interplay between inflammation, angiogenesis, myocardial perfusion, and myocardial function in patients with advanced chronic kidney disease (CKD). The project, conducted by Brigham & Women's Hospital Inc., aims to mechanistically explore cardiovascular health before and after kidney transplantation. Key objectives...
- This $799,287 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a prospective investigation of cirrhotic cardiomyopathy (CCM) in humans at Vanderbilt University Medical Center (VUMC). The study aims to address key unanswered questions about the prevalence, prognostic implications, and pathophysiology of CCM, a recognized but understudied complication of cirrhosis. The 5-year research project will conduct serial...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $180,174 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital of Philadelphia Research Institute. The grant will fund a study to develop a framework for designing the next generation of pediatric acute respiratory distress syndrome (ARDS) clinical trials. Key objectives include: 1) Comparing heterogeneity of treatment effect (HTE) analysis methodologies in a trial of pediatric...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $958,850 to Yale University to conduct research aimed at interrupting pro-inflammatory pulmonary-vascular cell interactions in order to reduce pulmonary capillary leak in critically ill children with bronchiolitis. The overarching goal is to understand the regulation of interleukin-1 (IL-1) signaling in bronchiolitis, establish disease severity markers, and...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $185,720.00 to Vanderbilt University Medical Center (VUMC) to conduct a randomized clinical trial investigating the use of sedation-only versus sedation with neuromuscular blockade for emergency tracheal intubation of critically ill adults. The primary aim is to evaluate whether the sedation-only approach can prevent hypoxemia, which more than doubles the...
This federal Project Grant, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research to assess the timing and risk of developing Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) and sepsis in children following congenital heart defect (CHD) surgery. The $271,938 award to Vanderbilt University Medical Center (VUMC) will fund a deeper analysis of institutional databases to understand how this syndrome impacts survival in the pediatric cardiac ICU population. The research aims to elucidate the factors driving the high incidence of sepsis-related mortality in this patient cohort, with the goal of informing interventions to improve outcomes. This project aligns with the Cardiovascular Diseases Research program's objectives to foster innovative research and build research capacity in critical areas of cardiovascular health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $271.9k | 8/8/25 |