Project Grant K23HL171893
- The federal Project Grant award of $131,886 was provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, to conduct research on the use of bioimpedance as a tool to assess volume status and predict cardiovascular outcomes in patients with chronic kidney disease. The study aims to 1) examine the predictive capacity of changes in volume measured by bioimpedance for...
- This Project Grant award of $784,362.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Brigham & Women's Hospital Inc., will support research investigating the role of body composition, coronary microvascular dysfunction, and heart failure with preserved ejection fraction in characterizing adverse cardiometabolic disease phenotypes. The research aims to leverage novel imaging technologies to identify mechanisms of...
- This Project Grant award, valued at $167,400.00 and awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), will support research by Brigham & Women's Hospital Inc. to investigate how the immune mediator CD70 regulates endothelial metabolism and function, with the goal of identifying novel therapeutic targets for atherosclerotic cardiovascular disease. The 5-year project will comprehensively examine the role of CD70 in impairing endothelial...
- This Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The $138,523 award to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System) will fund research to investigate the distinct mechanisms underlying medial and intimal calcification in blood vessels, which are associated with increased cardiovascular disease risk. The research aims to systematically...
- The federal Project Grant award of $651,380 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a research study at Rhode Island Hospital focused on elucidating the molecular mechanisms by which coronary endothelial cells can survive and proliferate in low oxygen, low glucose conditions to help improve cardiac function after myocardial infarction. The key objectives are to investigate how reducing mitochondrial reactive oxygen species in...
- This $800,962 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at Brigham & Women's Hospital on the molecular mechanisms regulating fibroproliferative pulmonary vasculopathy in early pulmonary arterial hypertension (PAH). The research aims to investigate the role of the c-terminal Src kinase (CSK) and its regulation of Src kinase activation in the context of endothelial dysfunction and fibrosis,...
- This federal Project Grant award of $740,037, funded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on the regulation of angiogenesis (blood vessel formation) by cardiac fibroblasts following myocardial infarction. The key objectives are to investigate the temporal and spatial expression of pro- and anti-angiogenic factors secreted by cardiac fibroblasts to support cardiac repair and increase vascular...
- This federal Project Grant award, totaling $813,284.00 and provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports a research study on the relationship between acute kidney injury (AKI) and delirium in patients who have undergone cardiac surgery. The key objectives of this 5-year study are to: 1) determine the incidence and clinical characteristics of AKI-associated delirium in cardiac surgery patients, 2) delineate the signaling...
- This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), aims to apply state-of-the-art methods to evaluate the effectiveness of mechanical circulatory support (MCS) devices in treating acute myocardial infarction complicated by cardiogenic shock (AMI-CS). The $817,358 award, effective from August 19, 2025 to May 31, 2029, will support the following key activities: Appending individual patient...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $189,000.00 to the University of Utah to support a 5-year mentored research program and plan. The goal is to develop the principal investigator into an independent, patient-oriented clinical researcher focused on the pathophysiology of cardiogenic shock and its overlap with cardiorenal syndrome. The central hypothesis is that angiotensin II deficiency in a...
This federal Project Grant award of $193,984 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the interplay between inflammation, angiogenesis, myocardial perfusion, and myocardial function in patients with advanced chronic kidney disease (CKD). The project, conducted by Brigham & Women's Hospital Inc., aims to mechanistically explore cardiovascular health before and after kidney transplantation. Key objectives include assessing the impact of reduced CKD-related inflammation on coronary microvascular function and myocardial mechanics, leveraging transplantation as an observational model. The award has an ultimate completion date of July 31, 2030 and is a collaborative effort involving the hospital's parent organization, Partners Healthcare System Incorporated.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $194.0k | 8/13/25 |