Project Grant R21HD123143
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded a $427,625 Project Grant to Washington University's Office of Sponsored Research Services on August 6, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports a two-year research initiative (completion date: July 31, 2027) investigating the consequences of postpartum exogenous oxytocin administration on maternal-neonatal...
- The National Institute of Child Health and Human Development awarded The Washington University $922,870 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR). The award funds research to define the molecular mechanisms by which age-associated increases in ovarian tissue stiffness drive follicle inflammation and impair oocyte quality and fertility. The research tests the hypothesis that follicles detect age-related...
- The National Institute of Child Health and Human Development awarded The Washington University $427,625 on May 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate retinoic acid signaling and uterine epithelial cell fate determination. The research examines how retinoic acid signaling maintains uterine epithelial cell identity during adult homeostasis and tests hypotheses about the antagonistic relationship between retinoic acid and...
- The National Institute of Child Health and Human Development awarded The Washington University $396,259 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and validate uterine peristalsis imaging (UPI), a noninvasive diagnostic technology that provides objective, quantitative measurements of uterine peristalsis to predict frozen embryo transfer outcomes. Approximately 200,000 patients undergo frozen embryo transfer annually...
- The National Institute of Child Health and Human Development awarded The Washington University $135,378 on August 26, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of maternal gut bacteria in fetal growth and placental development. The research defines bacterial metabolic pathways that influence fetal growth through immune cell function at the maternal-fetal interface, with specific focus on macrophages in placental villi and...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $456,500 to The University of Texas Southwestern Medical Center on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds molecular characterization of human pregnancy-induced cervical epithelium through two research aims. First, the recipient will apply single-cell and spatial...
- The National Institute of Child Health and Human Development awarded The Washington University $125,142 on June 4, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how sodium-activated potassium channels (SLO2.1) modulate myoepithelial cell contractility and milk ejection during lactation. The project characterizes the role of SLO2.1 in regulating myoepithelial cell excitability, intracellular calcium signaling, and contractile responses...
- The National Institute of Child Health and Human Development (NICHD) awarded a $481,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Oregon Health & Science University (OHSU). The grant, awarded on September 1, 2024, will support research to investigate the mechanisms of neuroinflammation and perinatal brain injury associated with intrauterine infection by the bacteria Ureaplasma parvum. Specifically, the project aims to assess...
- The National Institute of Child Health and Human Development awarded University of California, San Diego $440,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate uterine neuronal innervation dynamics and immune function during the peripartum period. The research maps sympathetic, parasympathetic, and sensory neuronal subtypes across uterine layers in mice, describing their spatial and temporal distribution with proteomic...
- The National Institute of Child Health and Human Development awarded Worcester Polytechnic Institute $555,371 on June 1, 2026, to develop bioengineered in vitro models of uterine fibroids under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funded work creates two novel in vitro platforms—one with tunable transport properties and one modeling intramural uterine fibroids surrounded by myometrium—to study how altered signaling from sex hormones (estrogen...
The National Institute of Child Health and Human Development awarded The Washington University $427,625 on August 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate ubiquitination as a mechanism to improve oxytocin receptor responsiveness and uterotonic therapies in postpartum hemorrhage. The research addresses oxytocin receptor desensitization induced by prolonged oxytocin exposure—a barrier to effective labor management and postpartum hemorrhage prevention that contributes to rising maternal morbidity and mortality. The project will define the kinetics of oxytocin receptor ubiquitination, degradation, and recycling in human myometrial cells using quantitative flow cytometry, and test whether intermittent oxytocin administration can maintain receptor responsiveness by preventing K63-linked ubiquitination and receptor degradation. Performance takes place in St. Louis, Missouri, with a period of performance through July 31, 2028. This is a Project Grant assistance type award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/31/26 | ||
| Not listed | $427.6k | 8/26/26 |