Project Grant K99HD122916
- Grant Award Summary The Washington University, through its Office of Sponsored Research Services, received a $999,056 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award, effective September 1, 2025, through August 31, 2027, supports research investigating the role of the early-life gut microbiome on immunoglobulin A (IgA) and colonic immune development. The...
- The National Institute of Child Health and Human Development awarded the University of Washington $672,234 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, also designated 93.HDR). The project investigates metabolic regulation of immune cell function at the maternal-fetal interface. The research examines how nutrient availability and utilization impact immune cell phenotypes during pregnancy across all three trimesters. The work employs...
- The National Institute of Child Health and Human Development awarded Washington University $125,142 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to study the impact of bacterial vaginosis toxins on sperm function in mice and humans. The research investigates how lipopolysaccharide (a toxin produced by Prevotella) and vaginolysin (a toxin produced by Gardnerella) impair sperm capacitation, hyperactivated motility, and acrosomal...
- The National Institute of Child Health and Human Development awarded The Washington University $427,625 on May 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate retinoic acid signaling and uterine epithelial cell fate determination. The research examines how retinoic acid signaling maintains uterine epithelial cell identity during adult homeostasis and tests hypotheses about the antagonistic relationship between retinoic acid and...
- The National Institute of Child Health and Human Development awarded the University of Illinois $1,661,698 on September 10, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate transplacental immune pathways that contribute to fetal brain pathology during maternal influenza infection. The research employs spatial transcriptomics to define time-dependent phenotypic and functional shifts in immune and non-immune cells at the maternal-fetal...
- The National Institute of Child Health and Human Development awarded The Washington University $396,259 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and validate uterine peristalsis imaging (UPI), a noninvasive diagnostic technology that provides objective, quantitative measurements of uterine peristalsis to predict frozen embryo transfer outcomes. Approximately 200,000 patients undergo frozen embryo transfer annually...
- The National Institute of Child Health and Human Development awarded The Washington University $427,625 on August 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate ubiquitination as a mechanism to improve oxytocin receptor responsiveness and uterotonic therapies in postpartum hemorrhage. The research addresses oxytocin receptor desensitization induced by prolonged oxytocin exposure—a barrier to effective labor management and...
- The National Institute of Child Health and Human Development awarded Baylor College of Medicine $149,190 on January 1, 2026, to conduct research on microRNA-290's role in regulating maternal-fetal nutrient exchange during neural tube closure under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research investigates how microRNA-290 expressed in extraembryonic tissues, including the yolk sac, affects nutrient transport to embryos during early pregnancy...
- The National Institute of Child Health and Human Development awarded Trustees of Tufts College $1.072 million on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the mechanisms by which vaginal lactobacilli protect pregnancy outcomes. The research tests whether anti-inflammatory compounds produced by lactobacilli suppress inflammatory signaling that correlates with adverse pregnancy outcomes including preterm birth and reduced...
- The National Institute of Child Health and Human Development awarded Cincinnati Children's Hospital Medical Center $140,072 on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how white adipose tissue inflammation in pregnancy affects labor timing and preterm birth risk. The research uses a mouse pregnancy model to define sources of pro-inflammatory cytokine production throughout pregnancy, with specific focus on how white...
The National Institute of Child Health and Human Development awarded The Washington University $135,378 on August 26, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of maternal gut bacteria in fetal growth and placental development. The research defines bacterial metabolic pathways that influence fetal growth through immune cell function at the maternal-fetal interface, with specific focus on macrophages in placental villi and decidual tissue. The project tests the hypothesis that macrophages at the maternal-fetal interface mediate the effects of maternal gut microbiota on fetal growth through their response to microbial metabolites. Work uses arrayed collections of bacteria cultured from small intestinal samples obtained from undernourished women compared to bacteria from healthy controls, and employs gnotobiotic mice to model how gut bacteria from undernourished mothers impair fetal growth and placental efficiency through systemic inflammation during pregnancy. The research addresses intrauterine growth restriction (IUGR), for which no reliable therapeutic interventions currently exist. Performance occurs at The Washington University in St. Louis, Missouri. The period of performance runs through July 31, 2028. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $135.4k | 8/27/26 |