Project Grant R21HD119656
- The Project Grant award titled "UNDERSTANDING FUNCTIONS OF LTR RETROTRANSPOSON ACTIVATION IN PREIMPLANTATION DEVELOPMENT" is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $401,927 award supports research to understand how long terminal repeat (LTR) retrotransposons regulate zygotic gene activation and early embryogenesis. The research...
- This Project Grant award of $248,994 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which administers the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The award will fund research by the Washington University in New York, NY to investigate the mechanisms by which histone mutations affect chromatin structure, gene expression, and neural differentiation during development. The goal is to...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on identifying novel noncoding genetic mechanisms that contribute to developmental disorders. The $499,055.48 award, with a project period from November 1, 2024 to October 31, 2027, will fund research led by Dr. Chelsea Lowther at the Icahn School of Medicine at Mount...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $108,512 to fund research into the genetic factors underlying incomplete penetrance of RPSA variants that cause isolated congenital asplenia (ICA). The key objectives are to: 1) assess the impact of 5'UTR RPSA variants on mRNA translation using ribosome-profiling, polysome...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $121,920 to investigate the role of the RFT1 protein in regulating growth and developmental signaling. The research aims to elucidate how RFT1, which is associated with a rare congenital disorder of glycosylation, impacts the Hedgehog signaling pathway and downstream mTOR Complex...
- The National Institute of Child Health and Human Development (NICHD) awarded a Project Grant of $107,948 to New York University (NYU) on June 20, 2025 under the Child Health and Human Development Extramural Research (CFDA 93.865) program. The grant aims to enhance the understanding of motor neuron differentiation, which is critical for addressing spinal muscular atrophy and amyotrophic lateral sclerosis - neurological disorders affecting nearly 1 in 10,000 people globally. The research will...
- The Project Grant award titled "Asymmetric RNA Segregation in Neural Stem Cells" was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $392,004 grant will support research at the University of Washington to identify and characterize asymmetrically segregating RNA molecules in fly neural stem cells, with the goal of understanding how RNA partitioning contributes...
- This $681,829 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a comprehensive research initiative focused on characterizing the human "imprintome" - the set of genes and genomic regions that exhibit parent-of-origin specific regulation. The award to Children's Mercy Hospital in Kansas City, Missouri aims to leverage the...
- This $288,000 Project Grant was awarded on August 4, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research federal grant program (CFDA 93.865). The grant supports research conducted by the Van Andel Research Institute in Grand Rapids, Michigan to investigate fatty acid metabolism and identify potential therapeutic targets for treating mitochondrial fatty acid synthesis (MTFAS)...
- This federal Project Grant award was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $763,886 award, granted on March 12, 2025, supports a comprehensive research project at The Children's Hospital of Philadelphia (CHOP) to identify and functionally study RNA isoforms regulated by the ESRP1/2 proteins during epithelial-mesenchymal transition (EMT)....
This Project Grant award was made by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $422,916 award, with a performance period from August 1, 2025 to July 31, 2027, will support research to investigate the functional consequences of inosine triphosphate pyrophosphatase (ITPASE) deficiency and the impact of inosine misincorporation into the transcriptome. The research will utilize CRISPR/Cas9-derived ITPA-null human induced pluripotent stem cells, along with neurons and cardiomyocytes derived from them, to perform RNA sequencing, long-read sequencing, and ribosome profiling analyses. This work aims to elucidate the molecular and cellular mechanisms underlying the pathology of ITPASE deficiency, which causes a fatal infantile multisystem developmental disorder.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/2/25 | ||
| Not listed | $422.9k | 8/1/25 |