Project Grant R21HD119466
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA 93.865 Child Health and Human Development Extramural Research, provides $627,301 to support research on the neurosteroid allopregnanediol and its effects on promoting parental behavior. The award will fund a study to characterize the mechanisms of action of this neurosteroid, which has been shown to promote parental care in mice, in order to gain a better...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $2,255,352 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The award, effective September 15, 2025 through May 31, 2028, will fund research to determine the cellular and molecular mechanisms involved in the transfer of inflammatory signals across...
- The Trustees of Columbia University in the City of New York was awarded a $638,625.00 Project Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) on August 21, 2025. The project, titled "In Vivo Regulation of Progenitor Genome Organization and Cellular Diversity", aims to investigate how the physical organization of the genome in neural progenitor cells impacts their ability to generate diverse neuronal subtypes during brain...
- This federal Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting research on the role of decidual extracellular vesicles in mediating placental insufficiency. The $654,671 award, which commenced on August 1, 2025 and is scheduled for completion by April 30, 2030, is being conducted by the awardee, Yale University. The key...
- This Project Grant award of $226,608.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is funding research to identify the mechanistic link between fetal glucagon and placental nutrient delivery. The goal is to establish how fetal glucagon regulates placental lactogen secretion and uterine blood flow as an adaptive mechanism for matching nutrient supply to...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting research at Duke University to investigate the mechanisms behind nuclear plasticity and adaptation in the human placental syncytiotrophoblast (STB) during pregnancy. The $121,515 award, with a period of performance from August 1, 2025 to July 31, 2027, aims to...
- The U.S. National Institute of Child Health and Human Development (NICHD) awarded a $766,982 Project Grant to Carnegie Mellon University under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project aims to develop and validate a novel computational framework to simulate uteroplacental hemodynamics and placentation, with the goal of identifying metrics for early detection of pregnancy complications related to abnormal placental formation. This research...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
- This federal Project Grant award of $719,141, awarded on August 11, 2025 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support a longitudinal study comparing maternal prenatal distress effects between in-vitro fertilization (IVF) donor oocyte/embryo and non-donor oocyte pregnancies. The study aims to rigorously test the developmental origins of health and disease (DOHAD)...
- The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
The Trustees of Columbia University in the City of New York received a $452,375 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The award, effective from August 1, 2025 to July 31, 2027, supports research to investigate the reciprocal interactions between placental neurosteroid allopregnanolone and placental inflammatory processes. The study aims to assess the impact of endogenous and exogenous allopregnanolone on human placental inflammation and inflammatory signaling, with the goal of determining whether allopregnanolone or its analogs can prevent placental inflammatory responses. This research has implications for understanding and potentially mitigating diverse pregnancy pathologies associated with placental inflammation, such as preeclampsia and preterm labor.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $452.4k | 8/1/25 |