This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research provides $419,204 to The University of Kentucky Research Foundation to conduct research on rare genetic disorders associated with the SHOC2 gene. The project aims to use a zebrafish model to functionally characterize genetic variants found in patients with Noonan Syndrome with Loose Anagen Hair...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on elucidating the mechanisms underlying the pathogenesis of Hao-Fountain Syndrome, a rare genetic disease caused by USP7 variants. The $456,892 award, effective from August 1, 2025 to July 31, 2027, will support research to investigate the effect of Hao-Fountain Syndrome variants on the ERK1/2...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $121,920 to the University of North Carolina at Chapel Hill to investigate the role of the protein RFT1 in growth and developmental signaling. The research aims to elucidate how RFT1 regulates hedgehog signaling and downstream mTOR complex 2 pathways, which are key...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 "Child Health and Human Development Extramural Research", provides $561,640 to Duke University to conduct research on the signaling and cellular mechanisms that drive notochord patterning in zebrafish. The goal is to elucidate the clock mechanism that times the addition of new mineralized segments along the anterior-posterior axis, as well...
This federal Project Grant award of $294,408, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of Sonic Hedgehog signaling in regulating skeletal patterning during zebrafish fin regeneration. The research aims to identify key Sonic Hedgehog target genes and how they facilitate interactions between Sonic...
This federal Project Grant award, with ID K99HD119028, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $114,458 award, with a performance period from August 1, 2025 to July 31, 2027, will support research at Duke University to quantitatively investigate how zebrafish appendage regeneration encodes and processes size memory at the cellular...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $201,875 to Duke University to conduct research on the developmental origins of Sturge Weber Syndrome (SWS). The goal is to identify the specific fetal cell type and developmental timeframe in which the causative somatic mutation occurs, in order to generate a faithful animal...
The federal Project Grant award R01HD113778, totaling $2,245,254.00, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award aims to characterize the natural history and progression of Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS), an ultra-rare and often lethal metabolic disorder. Key objectives include: 1) Defining the spectrum of...
This Project Grant award of $743,926 from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will develop a resource of rigorously validated, translatable zebrafish models of previously undiagnosed human genetic diseases. The project will analyze genetic variants obtained from patients with rare, undiagnosed diseases through collaboration with clinical research consortia, and then generate humanized zebrafish models using CRISPR/Cas9 technology....
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to establish a novel zebrafish model of syndromic craniosynostosis. The $313,000 award to Emory University will enable comprehensive phenotypic, mechanistic, and genetic analyses of the craniosynostosis mutant zebrafish to better understand the underlying pathological mechanisms. The research aims to identify...