Project Grant R21HD112673

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $201,875.00 in funding to Duke University to conduct research on the developmental origins of Sturge-Weber syndrome (SWS). The goal is to address critical gaps in knowledge about the underlying somatic mutation and developmental timing that leads to the vascular malformations associated with SWS. The research team will use a novel mouse model to identify the specific cell type and developmental window when the causative mutation occurs, which will inform the generation of a faithful animal model for further mechanistic studies on SWS pathology. This 2-year research project runs from Feb 1, 2025 to Jan 31, 2027.