Project Grant 2533202

Award Date 7/1/25
Completion Date 5/31/26
Dollars Obligated $150K
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
South Hadley, MA 01075, USA
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This $149,936 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Mount Holyoke College to investigate the role of serotonin signaling in regulating axon morphology, connectivity, and behavior in fruit flies. The primary objectives are to:

  1. Determine the intracellular mechanisms by which the serotonin receptor 5-HT1A autoregulates axon outgrowth in serotonergic neurons.

  2. Examine how this autoregulation shapes anatomical circuits using a specific serotonergic neuron as a model.

  3. Understand how defects in serotonin autoregulation can alter vision-based behaviors.

This research aims to provide the first molecular mechanism of serotonin autoregulation and its impact on the development of the serotonergic system. The project will also provide multidisciplinary research experiences for students at an institution serving diverse and underrepresented populations. The award period is from July 1, 2025 to May 31, 2026.

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