This federal Project Grant award, totaling $2,004,633.00, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research to investigate the role of dysregulated RNA metabolism in maternal diabetes-induced neural tube defects (NTDs), which are a common birth defect. The research aims to determine how maternal diabetes represses the...
The National Institute of Child Health and Human Development (NICHD) awarded a $225,324 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Duke University to conduct research on the role of mitochondrial specialization in early embryonic development. The research, led by the Sherwood Lab, will utilize a newly developed in vivo toolkit in C. elegans to investigate how the mitochondrial electron transport chain (ETC) is regulated to meet the varying energetic...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $127,266 to The Regents of the University of Colorado to investigate the relationship between embryonic glucose homeostasis and neural tube closure. The key objectives are to: 1) Examine the role of the insulin receptor substrate 1 (IRS-1) protein in regulating cellular glucose consumption dynamics...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $2,468,757 to the University of Texas at Austin to conduct research on using magnetic resonance imaging (MRI) to assess maternal and fetal pancreas size and growth over the course of pregnancy. The research aims to establish a model for how maternal pancreas growth interacts with the...
This Project Grant award of $601,499 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate the impact of maternal obesity on mitochondrial function and offspring obesity development. The key objectives of this 5-year grant are to: 1) Determine if transfer of damaged mitochondrial cargo from circulating adipocyte extracellular vesicles (EVs) of obese...
This federal Project Grant award of $421,067.00, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research using kidney organoids to investigate the effects of in utero exposures, such as pregestational diabetes, on kidney development programs. The research aims to identify alterations to the normal differentiation of nephron progenitors and podocytes within the kidney...
The National Institute of Child Health and Human Development (NICHD) awarded a $704,154 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Oregon Health & Science University (OHSU). The purpose of this 5-year study is to investigate how maternal diet-induced metabolic dysfunction impacts epigenetic programming and developmental processes in rhesus macaque embryos and fetuses. Specifically, the researchers will assess alterations in DNA...
This Project Grant award of $765,571 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to investigate placental essential fatty acid (EFA) metabolism in gestational diabetes mellitus (GDM), with a focus on examining sexual dimorphism in cellular responses. The research aims to define the mechanisms underlying differential responses of male and...
This $178,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to develop an early life phenotyping framework for very preterm infants. The research aims to create 'perinatal phenotypes' by integrating variables such as reason for preterm birth, intrapartum care, and neonatal presentation, and then determine how these phenotypes contribute to...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 Child Health and Human Development Extramural Research, aims to identify the molecular mechanisms linking lactation to metabolism. The $751,710.10 award, granted on August 15, 2024, will fund investigations to understand the effect of maternal gestational diabetes on mammary epithelial cell (MEC) progenitor insulin signaling and MEC profiles, as...