Project Grant R21HD115142
- This federal Project Grant award, totaling $2,334,824.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The overriding goal of this 4-year grant, awarded to The Johns Hopkins University, is to understand the pathogenesis of neonatal necrotizing enterocolitis (NEC) - a leading cause of death from gastrointestinal disease in premature infants - and to develop...
- This $232,500 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) aims to address the challenge of necrotizing enterocolitis (NEC), a life-threatening intestinal disease in premature infants. The grant will support research to define the efficacy of human-derived placental stem cell extracellular vesicles (HPSC-EV) as a potential cell-free therapy, determine the cellular and transcriptional changes in NEC disease and therapeutic repair, and...
- The Project Grant award of $425,015 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to investigate the role of interindividual epigenetic variation in the development of necrotizing enterocolitis (NEC) in preterm infants. The two-year project, which commenced on August 1, 2025, will be conducted by Baylor College of Medicine, a prestigious private non-profit health sciences...
- The National Institute of Child Health and Human Development (NICHD) awarded a $398,750 Project Grant (CFDA 93.865) to the University of Oklahoma (OU) to conduct research on the role of creatine metabolism in necrotizing enterocolitis (NEC), a serious gastrointestinal disease affecting preterm infants. The research aims to test the hypotheses that creatine deficiency detrimentally affects preterm infant intestinal epithelial injury, while creatine supplementation can prevent NEC-like injury. The...
- This $178,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to develop an early life phenotyping framework for very preterm infants. The research aims to create 'perinatal phenotypes' by integrating variables such as reason for preterm birth, intrapartum care, and neonatal presentation, and then determine how these phenotypes contribute to...
- This federal Project Grant award of $630,847 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research conducted by Children's Mercy Hospital in Kansas City, Missouri to study the role of the SIGIRR gene in regulating intestinal barrier function and preventing necrotizing enterocolitis (NEC) in preterm infants. The key focus areas include...
- The National Institute of Child Health and Human Development (NICHD) awarded a $434,500 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Research Institute at Nationwide Children's Hospital. The grant, titled "NEOGX-III: Interpretable Machine Learning with Integrated Analysis of Maternal & Infant Electronic Medical Records for Unbiased Prediction of Need for Genome Sequencing in Level III NICUs," aims to develop a machine...
- This federal Project Grant award of $694,528.00, awarded on June 5, 2025 by the National Institute of Child Health and Human Development (NICHD), supports research into the learning and educational attainment of preterm and at-risk infants under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award recipient, Kaiser Foundation Hospitals, will leverage its integrated healthcare delivery system, patient data resources, and multidisciplinary research...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
- The federal Project Grant awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research to obtain new insights into gut dysbiosis and inflammatory signaling cascades related to metabolic disturbances in youth with perinatally acquired HIV (YPHIV) in sub-Saharan Africa. The $265,369 award to the Ann & Robert H Lurie Children's Hospital of Chicago...
The National Institute of Child Health and Human Development (NICHD) awarded a $431,750 project grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Ann & Robert H. Lurie Children's Hospital of Chicago. The grant, with a performance period from August 2025 to July 2027, supports research to investigate the role of the kynurenine pathway in the development of necrotizing enterocolitis (NEC), a serious gastrointestinal condition affecting premature infants. The research aims to better understand how neonatal intestinal endothelial cell metabolism and the kynurenine pathway impact intestinal microvascular development and the progression of NEC. Findings from this project may reveal new therapeutic targets for treating NEC, a major cause of morbidity and mortality in preterm infants.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 8/6/25 |