The University of Colorado-Denver was awarded a $226,608 Project Grant by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund research to identify the mechanism by which fetal glucagon regulates placental nutrient delivery as an adaptive mechanism for matching nutrient supply to fetal metabolic demand under adverse uterine conditions. Specifically,...
This Project Grant award of $147,486, provided by the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research, aims to investigate the role of the placenta-brain axis in Down Syndrome (DS) development. The research, conducted by The Johns Hopkins University, will examine how increased dosage of human chromosome 21 genes, specifically APP and SOD1, impact placental function and the secretion of neuroactive...
The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $121,515 to Duke University to investigate nuclear plasticity in the human placental syncytium during pregnancy. The research aims to: 1) Determine the mechanism of nuclear subtype adaptation in the syncytiotrophoblast (STB) cell during stress, and 2) Map the unique...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,576,519 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the role of the RNA methyltransferase METTL3 in mammalian placental development and maintenance. The research aims to elucidate how METTL3-mediated RNA modifications regulate...
This federal Project Grant award for $152,816.00, provided by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to investigate the link between Down's syndrome (trisomy 21) and placentation defects. The research will focus on: Identifying transcriptional differences in implantation-stage trophoblasts between trisomy 21 and euploid induced pluripotent stem cell lines through RNA-sequencing. Assessing the...
The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
The National Institute of Child Health and Human Development (NICHD) awarded a $429,000 Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, to develop a new imaging tool to assess placental hemodynamics during pregnancy. The study aims to determine if Subharmonic Aided Pressure Estimation (SHAPE) using contrast-enhanced ultrasound can provide a safe, non-invasive, and real-time method...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $430,375 to The Regents of the University of Colorado to conduct research on defining the association between Down's syndrome (Trisomy 21) and placentation defects. The research aims to identify transcriptional differences in implantation-stage trophoblasts derived from induced pluripotent stem cells, as well as assess the role of the NRIP1 gene in trophoblast...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 - Child Health and Human Development Extramural Research, will fund a computational modeling study to investigate uteroplacental hemodynamics and its implications for placental development and fetal health. The $766,982 award to Carnegie Mellon University will develop and validate a novel computational framework to simulate uteroplacental...