This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,399,467 to The Johns Hopkins University to investigate the cellular and molecular mechanisms by which integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) leads to weight gain, particularly in women. The research aims to: 1) define the molecular pathways by...
The National Institute of Child Health and Human Development (NICHD) awarded a $158,000 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Rush University Medical Center. The grant, awarded on September 6, 2023, will fund a study to determine the long-term effects of in-utero and lactational exposure to dolutegravir-based combination antiretroviral therapy (CART) on bone and fat tissues. The research aims to address a critical clinical...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,314,701.00 to support research focused on optimizing dolutegravir-based antiretroviral therapy (ART) in children and adolescents. The primary award recipient is the University of Florida, which will oversee the overall research project. The project includes sub-awards to Kwame Nkrumah University of Science...
This Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, will provide $259,818 to the University of North Carolina at Chapel Hill to characterize adherence and estimate per-protocol effects for pediatric use of the antiretroviral drug dolutegravir. The objectives are to (1) identify barriers to pediatric dolutegravir combination therapy adherence, and (2) estimate per-protocol...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $232,500 to The Johns Hopkins University to investigate virologic determinants of very early antiretroviral treatment responses in infants with in utero HIV-1 infection. The key objectives are to create infectious molecular clones from the HIV-1 genetic sequences of study...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, provides $1,188,296 to Brown University to develop and refine a multicomponent behavioral intervention to address both HIV viral suppression and postpartum weight retention among postpartum women living with HIV in South Africa. The 3-year project, starting on September 15, 2024, aims to: 1) refine the planned intervention through participatory...
This federal Project Grant award of $756,077, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a 5-year research study on the long-term immunologic, cardiovascular, metabolic, and neurocognitive consequences of inflammation in children with perinatal HIV in sub-Saharan Africa. The primary objectives are to assess the durability of inflammation and immune...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,376,850 to conduct research on interventions to protect HIV-exposed uninfected (HEU) infants against severe infections. The research aims to: Define immunogenomic and metabolomic profiles that explain HEU immune dysfunctions; Compare gut and respiratory microbiome...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $244,328 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the impact of in utero HIV and antiretroviral exposure on the placenta and birth weight. The project aims to simultaneously measure antiretroviral (ARV) levels in pregnant women and their children's hair to...
This $244,814 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will fund a mixed-methods research study to investigate the social and behavioral drivers of HIV risk among South African adolescent girls and young women (SA-AGYW). The primary objectives are to: 1) conduct secondary analyses of baseline data from an existing HIV prevention intervention to examine the roles of mental health...