The National Institute of Child Health and Human Development (NICHD) awarded a $158,000 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Rush University Medical Center. The grant, awarded on September 6, 2023, will fund a study to determine the long-term effects of in-utero and lactational exposure to dolutegravir-based combination antiretroviral therapy (CART) on bone and fat tissues. The research aims to address a critical clinical concern, as dolutegravir-based CART has become the recommended first-line treatment for all people living with HIV, including pregnant women. The study will leverage banked bone and fat samples from an 18-month rat experiment to test the hypothesis that developmental exposure to dolutegravir-based CART will cause lasting deleterious effects on bone mass, quality, and fat tissue. The findings will begin to establish the long-term consequences of early dolutegravir exposure and identify the driving mechanisms.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $158.0k | 9/6/23 |