This Project Grant award from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $756,077 to Indiana University Indianapolis to conduct a 5-year study on the long-term immunologic, cardiovascular, metabolic, and neurocognitive consequences of inflammation in children with perinatal HIV. The research aims to determine whether viral suppression from long-term antiretroviral therapy dampens immune activation and the pathogenic mediators of inflammation in this population. The study will assess inflammatory biomarkers, immune cell profiles, viral reservoir size, and intestinal permeability, and correlate these with clinical outcomes including cardiovascular function, insulin resistance, and neurocognitive performance. A sub-award to the Mkomani Clinic Society in Kenya will support the enrollment of participants, clinical assessments, sample processing, and data analysis. The findings from this comprehensive, longitudinal study have the potential to identify screening biomarkers and interventions to mitigate HIV-related comorbidities in adolescents and young adults with perinatal HIV infection.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $756.1k | 8/7/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
10373S | Mkomani Clinic Society | Project Grant R01HD113487 | $82.6k | 1/28/25 |