This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $828,580 to Yale University over the period of August 6, 2024 to July 31, 2029. The award supports the research of Dr. Samuel Gentle, who aims to reduce morbidity and mortality in children with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) through novel translational and...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $2,024,790 to the Research Institute at Nationwide Children's Hospital to develop a novel probiotic delivery system using Limosilactobacillus reuteri (LR) to prevent and treat neurodevelopmental impairment (NI) in premature infants. The key objectives are to determine the extent to which LR's...
This $178,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to develop an early life phenotyping framework for very preterm infants. The research aims to create 'perinatal phenotypes' by integrating variables such as reason for preterm birth, intrapartum care, and neonatal presentation, and then determine how these phenotypes contribute to...
This federal Project Grant award of $1,544,693, awarded by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 "Child Health and Human Development Extramural Research", supports research to characterize gastrointestinal (GI) disorder trajectories and develop predictive models of GI symptom risk profiles and treatment response for autistic sub-groups. The primary awardee, the University of Southern California, will conduct this multi-method research...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to establish patient-reported outcome measures that can refine risk stratification and identify barriers to post-discharge specialty care for preterm infants with bronchopulmonary dysplasia (BPD). The $586,021 award, effective February 1, 2025, supports efforts to recruit at least 750 infants from 15 sites in the Children's Hospitals Neonatal Consortium to link neonatal...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $412,500.00 in funding to the University of South Florida (USF) to conduct a longitudinal study of gut dysbiosis in anemic preterm infants. The goal is to determine the hematocrit threshold associated with gut microbiome changes and how anemia development influences the microbiome and host interactions...
This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a comparative study investigating the mechanistic effects of human milk feeding on neurodevelopment in preterm infants. The $239,399 award to the Regents of the University of Idaho will utilize a neonatal piglet model to examine how human milk feeding influences intestinal barrier function,...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $102,168 to support a research study conducted by the University of California, San Francisco (UCSF). The study aims to evaluate the effects of state-level initiatives to reduce early-term elective deliveries (EEDS) on maternal and newborn outcomes, as well as disparities in these outcomes. The...
This $314,827 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund a randomized clinical trial to evaluate a modified vertical sleeve gastrectomy (MVSG) procedure compared to the conventional vertical sleeve gastrectomy (CVSG) for patients with obesity and gastroesophageal reflux disease (GERD). The study aims to determine if the MVSG technique...
This Project Grant award of $291,523 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop an AI-driven Total Parenteral Nutrition (TPN) platform for premature newborns in neonatal intensive care units (NICUs). The key goals are to create standardized TPN units for cost-effective and personalized nutrition, and validate the TPN2.0 platform against the best standard of...
This Project Grant award of $1,160,229, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund a pilot randomized trial comparing transpyloric to gastric tube feeding in very preterm infants with bronchopulmonary dysplasia (BPD). The study aims to determine whether transpyloric feeding safely and effectively reduces gastroesophageal reflux disease (GERD) in this patient population. The research will use esophageal pH-impedance testing to objectively evaluate GERD before and during the 2-week feeding interventions, and will also analyze biomarkers related to GERD and lung aspiration. The results are expected to inform evidence-based GERD diagnosis and feeding practices for preterm infants with BPD, and lay the groundwork for a larger definitive multicenter trial. The project will be conducted by The Leland Stanford Junior University and is scheduled to run from September 2024 through August 2026.