This Project Grant award, valued at $378,272 and provided by the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 (Child Health and Human Development Extramural Research), will fund research to explore the use of inter-alpha inhibitor proteins (IAIP) as a potential therapeutic agent for necrotizing enterocolitis (NEC) - a serious inflammatory condition affecting premature infants. The research aims to obtain proof-of-concept for IAIP replacement...
This $159,362 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to characterize how breast milk IgA shapes the development of the preterm infant gut microbiome and promotes resistance to pathobionts. The primary goals are to: 1) Determine if maternal IgA binding restricts colonization of Enterobacteriaceae and promotes the establishment of obligate anaerobes...
This $725,077 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to study the immunopathogenesis of necrotizing enterocolitis (NEC) in preterm infants and develop innovative interventions to interrupt the deleterious inflammatory response that leads to this devastating intestinal disease. The primary recipient, the University of North Carolina at Chapel Hill, will leverage...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $300,000 Project Grant to Siolta Therapeutics Inc. on August 14, 2023. The purpose of this grant is to develop STMC-106, a multistrain live biotherapeutic product (LBP), for the prevention and treatment of necrotizing enterocolitis (NEC) in preterm infants. The key objectives of this project are: 1) to identify combinations of therapeutic...
This $178,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund a study to create a novel patient selection framework for early life interventions targeting infection, inflammation, and growth outcomes in very preterm infants. The study aims to leverage a registry of over 3,600 very preterm infants and their mothers to develop perinatal phenotypes that...
This Project Grant award of $630,847 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by Children's Mercy Hospital in Kansas City, Missouri. The research aims to investigate how the genetic regulator SIGIRR promotes intestinal barrier function and prevents necrotizing enterocolitis (NEC), a life-threatening condition in preterm infants....
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $174,114 to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on signaling pathways that regulate intestinal epithelial cell injury in necrotizing enterocolitis (NEC), a devastating gastrointestinal disease that affects premature infants. The studies aim to...
The National Institute of Child Health and Human Development (NICHD) awarded a $398,750 Project Grant (CFDA 93.865) to the University of Oklahoma (OU) to conduct research on the role of creatine metabolism in necrotizing enterocolitis (NEC), a serious gastrointestinal disease affecting preterm infants. The research aims to test the hypotheses that creatine deficiency detrimentally affects preterm infant intestinal epithelial injury, while creatine supplementation can prevent NEC-like injury. The...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $248,999 to support research aimed at discovering novel therapeutics for inflammation-induced preterm birth. The primary goals of this 3-year award are to: 1) Optimize a high-throughput screening assay to identify small-molecule compounds that can modulate proinflammatory cytokine release from...
This Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate how the gut microbiome composition impacts gastrointestinal (GI) and central nervous system (CNS) function in a mouse model of autism spectrum disorder (ASD). The $430,375 award to the partnership between Henry Ford Health and Michigan State University Health Sciences will...