Project Grant R21HD113311

Award Date 9/6/23
Completion Date 8/31/25
Dollars Obligated $432K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Newark, NJ 07107, USA
Similar Awards
The National Institute of Child Health and Human Development (NICHD) awarded a $463,360 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Weill Medical College of Cornell University for a project titled "Maternal Milk Cytokines Activate Cognate Receptors in the Neonatal Esophagus to Program Adult Social Behavior." The research aims to determine how maternal milk cytokines interact with receptors in the neonatal esophagus to influence brain...
The National Institute of Child Health and Human Development (NICHD) awarded a 5-year, $504,283 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the Icahn School of Medicine at Mount Sinai. The grant will fund a study examining the epidemiology and risk factors for autism spectrum disorder (ASD) in children born preterm, and determine if the genetic architecture of ASD differs between preterm and term-born children. The study will create a prospective...
The National Institute of Child Health and Human Development (NICHD) awarded a $424,875 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Maryland, Baltimore (UMB) to investigate the role of placental serum amyloid A (SAA) isoforms in response to sub-chronic maternal inflammation and explore whether inhibition of the SAA2 isoform using small interfering RNA (siRNA) can alleviate preterm birth and adverse fetal outcomes. The project aims...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $414,026 to Childrens Hospital Medical Center in Cincinnati, Ohio to conduct research on determining the mechanism by which maternal interleukin-10 (IL-10) restricts fetal emergency myelopoiesis, with the goal of improving neonatal outcomes. The research aims to identify the IL-10-responsive...
The National Institute of Child Health and Human Development (NICHD) awarded a 5-year, $415,832 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Nebraska Medical Center (UNMC) to investigate the mechanisms by which severe anemia and red blood cell transfusions (RBCT) induce and exacerbate brain inflammation in anemic neonates, leading to long-term neurodevelopmental impairment. The research aims to elucidate how anemia and RBCT...
The National Institute of Child Health and Human Development (NICHD) awarded a $481,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Oregon Health & Science University (OHSU). The grant, awarded on September 1, 2024, will support research to investigate the mechanisms of neuroinflammation and perinatal brain injury associated with intrauterine infection by the bacteria Ureaplasma parvum. Specifically, the project aims to assess...
This $224,250 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to investigate the interplay between the transcriptional co-regulator CITED2 and maternal folic acid in regulating neocortical development. The research, conducted by Syracuse University, will use CITED2 conditional knockout mouse models to examine how genetic, epigenetic, and maternal nutrition...
This Project Grant award of $147,486, provided by the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research, aims to investigate the role of the placenta-brain axis in Down Syndrome (DS) development. The research, conducted by The Johns Hopkins University, will examine how increased dosage of human chromosome 21 genes, specifically APP and SOD1, impact placental function and the secretion of neuroactive...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is funding a research study to investigate the molecular mechanisms behind the sex-specific deficits observed in neurodevelopmental disorders like Autism Spectrum Disorder (ASD). The $431,750 award, active from May 1, 2025 to April 30, 2027, will support researchers at Rutgers, The State University of New Jersey in conducting studies using mouse models to...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $431,750 to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The funding will support a 2-year investigation into the neurobiological mechanisms underlying heterogeneity in social behavior development among young...

The National Institute of Child Health and Human Development (NICHD) awarded a $431,750 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Rutgers, The State University of New Jersey, to investigate how the cytokine interleukin-6 (IL-6) affects the proliferation, specification and gene expression of human and mouse secondary neural progenitor cells. The goal is to establish IL-6 as a key target for intervention to prevent neurodevelopmental disorders like autism, schizophrenia and ADHD, which have been linked to elevated fetal IL-6 levels. The research will generate human induced pluripotent stem cell-derived secondary neural progenitors to determine how IL-6 alters their development, and perform comparative studies on mouse subventricular zone cells. Additionally, the project will conduct fate mapping analyses in mice treated with IL-6 during a developmental stage analogous to 24 weeks of human gestation, to assess the histogenesis of brain regions implicated in complex neurodevelopmental disorders.

Generated 8/13/24, 7:32 AM