This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $117,959 to the University of California, San Diego (UCSD) to conduct research on the impact of sex hormones and mechanical stretch on pelvic floor muscle structure and function during pregnancy and postpartum. The research involves two main components: 1) in vitro cell culture experiments to examine the...
This Project Grant award for $1,708,120.00 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to develop less invasive, novel intervention strategies for endogenous in utero repair of spina bifida. The key products or services to be delivered through this 5-year grant include: Determining the therapeutic efficacy of amniotic fluid-based cell-free strategies to modulate the in...
This $1,459,877 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to develop a bioinspired composite scaffold for repairing pubovisceral muscle enthesis (PVME) injuries in women following vaginal childbirth. The primary recipient, Magee-Womens Research Institute and Foundation, will utilize transperineal ultrasound, MRI shape modeling, and...
This $328,496 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports the development of a novel hydrogel film and applicator system to reduce pain experienced during sexual intercourse by women with vulvodynia and vestibulodynia. The goal is to create a non-pharmaceutical solution that can mitigate pain receptor activity and dissipate pressure on sensitive vulvar...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $424,600.00 to The Leland Stanford Junior University to conduct research on the cellular mechanisms and microenvironment of the vagina in women with recurrent pelvic organ prolapse (POP) after previous POP surgery. The research aims to 1) examine the effects of POP surgery on the human...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.279 Drug Use and Addiction Research Programs) will provide $1,516,765 to the University of California, Los Angeles (UCLA) to validate an innovative near infrared spectroscopy (NIRS) technology as a non-invasive method for assessing pelvic floor muscle fitness in patients with myofascial pelvic pain (MPP). The goal is to establish parameters to quantify the severity and spatial patterns of...
The National Institute of Child Health and Human Development (NICHD) awarded a $424,875 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Maryland, Baltimore (UMB) to investigate the role of placental serum amyloid A (SAA) isoforms in response to sub-chronic maternal inflammation and explore whether inhibition of the SAA2 isoform using small interfering RNA (siRNA) can alleviate preterm birth and adverse fetal outcomes. The project aims...
The National Institute of Child Health and Human Development (NICHD) awarded Virginia Commonwealth University (VCU) a $232,875 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to study gastrointestinal dysfunction in Down syndrome. The 2-year grant, awarded on July 3, 2024, will investigate the mechanisms underlying altered bowel smooth muscle function in a mouse model of Down syndrome, with a focus on voltage-gated calcium channels. The...
This $248,999 federal Project Grant was awarded on September 1, 2024 by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research at Vanderbilt University Medical Center to discover novel therapeutics for managing infection-induced preterm birth. The key objectives are to: 1) Optimize a high-throughput screening assay to identify small molecules that can modulate...
The National Institute of Child Health and Human Development (NICHD) awarded a $743,287 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Oregon Health & Science University (OHSU) to conduct a multi-disciplinary study aimed at uncovering novel insights into endocervical mucus secretion. The goal of the project is to better understand how female sex hormones regulate the biophysical properties of endocervical mucus, with the long-term objective of...