Project Grant R21GM160866
- This federal Project Grant award of $645,712 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of chemical biology tools to provide critical insights into protein post-translational modification (PTM) networks, with a focus on glycation and ubiquitination, in living cells. The research aims to unlock previously unattainable information to address questions about the role of these...
- This $1,977,264 federal Project Grant, awarded by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a novel multimodal imaging platform that combines fluorescence super-resolution and tomographic polarized light imaging. The project will create open-source computational imaging tools to recover the dielectric tensor in multiple scattering samples using...
- This federal Project Grant award of $382,026.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to synthesize, characterize, and implement a palette of target-specific organic dyes with biologically-responsive long-lived fluorescence lifetimes. The goal is to develop optical reporting dye technology that can yield two long-lived fluorescence lifetimes that are mechanoresponsive,...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $316,668 to Montana State University from February 1, 2025 to January 31, 2030. The funding supports the Lemon Group's research at the interface of synthetic chemistry and protein biochemistry to enhance the molecular understanding of various pathologies and improve patient outcomes. Key focus areas include developing...
- This $378,715 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development of novel aptamer-based biosensing probes for high-resolution chemical imaging of multiple analytes at the single-cell level. The Florida State University (FSU) Lazenby Lab, the awardee, is leveraging electrochemical techniques and aptamer-based sensing platforms to expand the scope of molecules...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $330,076 to Trestle Optics LLC, a small disadvantaged business located in Irvine, California. The award supports the development of a novel photothermal microscopy platform integrated with spatial light interference imaging. This innovative instrument is designed to enable non-destructive profiling and mapping of...
- This $457,088 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of imaging tools to improve the activity of endolysins, a promising alternative to traditional antibiotics for treating antibiotic-resistant bacterial infections. The key products and services to be delivered include: Synthesizing a panel of internally quenched substrates to assess the activity of...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $304,196 to Laser Bioanalytics LLC for the development of a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable improved mass spectrometry structural analysis and imaging of lipids, which are important cellular components relevant to disease diagnosis...
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
This federal Project Grant award of $378,672 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop a bioorthogonal chemistry-based live-cell imaging technology to study protein lactylation at the spatiotemporal scale. The project, conducted by Bucknell University, will design a fluoro-substituted L-lactic acid metabolic analog that reacts via a novel bioorthogonal fluorine-selenol substitution reaction to trigger aggregation-induced emission (AIE) in a nucleocytoplasmic-localizing imaging probe. This will enable high-resolution imaging of intracellular lactylated proteins, providing insights into the spatiotemporal dynamics of this recently discovered post-translational modification and its implications for conditions like autoimmunity, inflammation, and cancer. The project is expected to run from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $378.7k | 8/14/25 |