Project Grant R21EY037416
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $902,000 to the University of California, San Francisco for a two-year project (September 1, 2025 – August 31, 2027) to conduct multimodal characterization of a novel inherited mouse model of glaucoma. The primary deliverables include comprehensive phenotypic characterization of GLIS1 knockout mice across two genetic backgrounds, evaluating structural and functional...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded Oregon Health & Science University a $598,108 Project Grant beginning September 1, 2025, with completion targeted for April 30, 2030. This multidisciplinary research initiative will develop innovative optical coherence tomography (OCT) imaging technologies and objective biomarkers to assess photoreceptor function and integrity in retinal disease. The project addresses a...
- Federal Grant Award Summary Oregon Health & Science University received a $264,435 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective May 1, 2026 through April 30, 2031. This award funds research to define the pathophysiology of microcephaly and chorioretinopathy (MCCRP), a neurodevelopmental disorder characterized by abnormal vascular development in the retina and brain. The research will investigate the role of the gamma-tubulin...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $173,016 to the Whitehead Institute for Biomedical Research under the Vision Research program (CFDA 93.867) for a project grant effective August 1, 2025, through July 31, 2027. This award supports systematic identification and mechanistic characterization of novel oxidative protective genes to prevent retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD). The research involves...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $384,364 to the University of Nebraska Medical Center under the Vision Research program (CFDA 93.867) beginning September 1, 2025, through May 31, 2030. This project grant funds research to investigate the molecular mechanisms underlying age-related cataracts (ARC) by examining the dysregulation of the BMAL1 (Brain and Muscle ARNT-Like Protein 1) clock protein and NRF2 (NFE2-Related Factor 2) antioxidant pathways in the...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded the University of California, Davis $423,767 under the Vision Research program (CFDA 93.867) for a two-year project period beginning June 1, 2025 and concluding May 31, 2027. The research project investigates the role of myeloid cells as mediators of glaucomatous axon degeneration and evaluates whether nicotinamide adenine dinucleotide (NAD+)-boosting interventions provide neuroprotection through anti-inflammatory...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant of $497,740 to the University of Illinois (Chicago, IL) under the Vision Research program (CFDA 93.867), effective April 1, 2026, through March 31, 2031. Under the direction of Principal Investigator Elmira Jalilian, this research project will generate scientific findings and empirical data examining neuro-epithelial interactions in corneal disease and repair, with particular focus on how corneal nerves...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Johns Hopkins University a Project Grant totaling $199,122.50 (awarded June 1, 2025) under the Vision Research program (CFDA 93.867) to support fundamental research on starburst amacrine cells (SACs) in human retinal organoids. The project will deliver scientific research products including empirical findings on the developmental mechanisms and cellular connectivity of SACs, which are specialized interneurons critical to...
The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The University of Iowa a $440,263 Project Grant (awarded May 1, 2026; completion April 30, 2028) to investigate osmotic regulation mechanisms in cone dystrophy with supernormal rod response (CDSRR). This research project will deliver empirical findings on the pathophysiology of CDSRR, a genetic form of retinal degeneration caused by mutations in the potassium channel gene KCNV2 that leads to early-onset vision loss and progressive macular degeneration. The research will employ state-of-the-art imaging biomarkers and transcriptomics analysis in mouse models to evaluate how loss of potassium channel function disrupts osmotic homeostasis in photoreceptors, with the objective of identifying the mechanisms driving macular degeneration and informing future sight-preserving therapeutic interventions. The project addresses a critical knowledge gap in vision science by testing the hypothesis that impaired potassium clearance in CDSRR photoreceptors triggers chronic osmotic stress signaling due to accumulation of metabolic waste. By characterizing osmotic dysregulation in this disease model, the research will generate foundational scientific data intended to support the development of treatments for this currently untreatable hereditary vision disorder that affects quality of life beginning in childhood.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.3k | 4/17/26 |