This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $939,708 to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the role of histone deacetylases HDAC6 and SIRT1 in the development of diabetic retinopathy, a leading cause of blindness. The research aims to study how an imbalance between HDAC6 and SIRT1 contributes to retinal vascular senescence and diabetic microangiopathy, as well...
The U.S. National Eye Institute (NEI) awarded a $184,117 Project Grant (CFDA 93.867 - Vision Research) to Oakland University to determine the role of G-coupled protein receptors GPR31 and GPR39 in the pathogenesis of diabetic retinopathy. The project aims to investigate the affinities and substrate specificities of GPR31 and GPR39 for 12- and 15-HETE metabolites in retinal endothelial cells and Müller cells under normal and hyperglycemic conditions. It will also examine the effects of GPR31 or...
The National Eye Institute (NEI), under the Department of Health and Human Services, awarded a $440,806 Project Grant (CFDA 93.867 - Vision Research) to The Research Foundation for the State University of New York (RF SUNY) to study the role of the molecular chaperone p58IPK in retinal neurons under diabetic conditions. The goal is to define the in vivo function of p58IPK in regulating protein and lipid homeostasis through the integrated stress response and lipid glycosylation pathways, and to...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will fund a study to evaluate the impact of patient, neighborhood, and community characteristics on diabetic retinopathy screening and monitoring. The central hypothesis is that neighborhood and community factors, as measured by the Area Deprivation Index (ADI), will be as or more important than individual patient characteristics in explaining non-adherence to...
This Cooperative Agreement award from the National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), supports a longitudinal study on the long-term ocular sequelae and biological determinants of post-acute Ebola virus disease (PASE). The $1,896,479 award, effective August 1, 2025 through May 31, 2030, will leverage the existing Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) cohort to investigate the prevalence and...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will fund research to investigate the mechanisms by which Zika virus (ZIKV) infection disrupts the blood-retinal barrier (BRB) and causes ocular complications. The principal investigator will receive $121,090 over the period of Sep 30, 2024 to Aug 31, 2026 to pursue the following aims: 1) Investigate the role of Angiopoietin/Tie-2 and Sphingosine-1-phosphate signaling in...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), aims to define the role of the RIG-I protein in the pathogenesis of glaucoma and the response to viral infections. The $603,251 award, effective from July 1, 2025 to April 30, 2030, will support the following key activities: Elucidating the molecular mechanisms by which RIG-I variants cause glaucoma in a mouse model through genetic perturbation, histological, and single-cell...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $253,500.00 to the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The research aims to optimize an in vitro outer blood-retina barrier model, generate isogenic models with different APOE...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) will support $2,282,280 in research over the period from August 2024 to May 2028. The grant will fund investigations into the role of HIV-derived proteins, CD4+ T cells, and the protein podocan-like protein 1 (PODNL1) in the development of pulmonary vascular disease (PVD) among...
The National Eye Institute (NEI) awarded a $510,689 Project Grant under CFDA 93.867 (Vision Research) to the Georgia Tech Research Corporation. The grant, effective March 1, 2025 through February 28, 2030, will fund research to define the functional organization and retinotopic precision of top-down feedback circuitry from the anterior cingulate cortex to primary and higher visual cortical areas, as well as the functional organization and efficacy of these top-down feedback projections during...