Project Grant R01EY037225

Award Date 7/1/25
Completion Date 4/30/30
Dollars Obligated $603K
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Michigan, USA
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  1. Elucidating the molecular mechanisms by which RIG-I variants cause glaucoma in a mouse model through genetic perturbation, histological, and single-cell transcriptomic analyses.

  2. Identifying triggers, including viral infections such as Zika, that may exacerbate the phenotypic variability observed in Singleton-Merten Syndrome, a rare immunogenetic disorder associated with glaucoma.

  3. Testing therapeutic interventions to rescue the effects of RIG-I activation and glaucoma in patient cells and the mouse model, with a focus on type I interferon blockade.

The overarching goal is to define the immune mechanisms driving glaucoma, which could inform the understanding of both rare immunogenetic syndromes and more common forms of glaucoma potentially linked to RIG-I activation.

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