Project Grant R21EY037063
- This $240,750 federal Project Grant award from the National Eye Institute's Vision Research program (CFDA 93.867) aims to investigate the role of neural-glial-vascular signaling in the development of the eye's vasculature. The research has two main objectives: 1) Characterizing vasculature development and how it is altered in mice with modified retinal waves, using quantitative approaches and live imaging, and 2) Establishing the maturation of the glial-vascular unit through immunofluorescence...
- This $422,125 Project Grant award from the National Eye Institute's Vision Research program is funding research to investigate the role of cholesterol homeostasis in the treatment of demyelinating eye diseases. The research aims to develop neuroprotective and neuroreparative therapies that can prevent retinal ganglion cell degeneration and promote remyelination to preserve visual function. The award was made to the University of Miami, which has extensive expertise in providing specialized...
- This Project Grant award from the National Eye Institute's Vision Research program (CFDA 93.867) is supporting research at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate the role of neuronal activity on retinal angiogenesis and blood-retina barrier (BRB) maturation. The $248,999 award, effective from May 1, 2025 to April 30, 2028, aims to elucidate how neuronal synaptic activity, specifically cholinergic and glutamatergic neurotransmitters,...
- This Project Grant award of $253,500.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research by the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The researchers will optimize an in vitro human outer blood-retina barrier model to study AMD phenotypes and...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $595,302 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, for the period of April 1, 2025 to March 31, 2030. The project aims to investigate how glucose and lactate support photoreceptor health and function in order to develop new treatment strategies to prevent vision loss. Specifically, the researchers will determine whether the retinal...
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- The National Eye Institute awarded the University of Southern California a $443,408 federal Project Grant under the Vision Research program (CFDA 93.867) to develop a novel therapeutic intervention using oxygen nanobubbles to treat retinal ischemia and prevent vision loss. The project aims to: 1) formulate a consistent oxygen nanobubble formulation and evaluate its physical/biochemical properties; 2) identify the optimal administration timing to improve ischemia-induced impairments of retinal...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, provides $590,160.00 in funding to characterize photoreceptor precursor cells for retinal transplantation. The research aims to improve understanding of photoreceptor development and investigate avenues for photoreceptor regeneration to restore vision, as retinal degenerative diseases...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $144,200 Project Grant to Pennsylvania State University's Milton S. Hershey Medical Center. The grant, effective June 1, 2025 through November 30, 2027, will fund research to characterize the molecular mechanisms underlying increased levels of the protein REDD1 in the retina due to diabetes, and explore alternative intervention strategies for preventing retinal complications caused by...
- This federal Project Grant award of $234,000.00 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to enhance stem cell restoration of intraocular pressure (IOP) homeostasis through senolytic treatments. The key goals are to study how senescent trabecular meshwork (TM) cells in glaucoma patients affect IOP regulation, and to explore whether clearing these senescent cells using senolytic drugs can improve the effectiveness of...
This $427,625 Project Grant awarded by the National Eye Institute's Vision Research program on September 1, 2025 will support research to investigate the interplay between debris/dying cell clearance by specific retinal phagocytes and the potential for improving tissue healing in oxygen-induced retinopathy (OIR). The research, to be conducted by The Washington University, aims to determine whether cell-type specific expression of a chimeric efferocytosis (CHEF) receptor in Müller cells versus microglia can improve OIR outcomes. The project will also test a preclinical approach to express the CHEF receptor TELMO via mRNA-based nanoparticles. This exploratory R21 research grant is expected to provide key insights into leveraging efferocytosis mechanisms to enhance retinal tissue regeneration and healing for treating vision disorders like retinopathy of prematurity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 8/15/25 |