Project Grant R21EY036157
- This $460,625 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to Yale University. The grant will fund research to investigate the cellular and synaptic mechanisms underlying changes in retinal ganglion cell (RGC) activity following optic nerve injuries in mouse models of glaucoma. Specifically, the project aims to (1) determine the underlying mechanisms for altered RGC activity after increased intraocular pressure or...
- This federal Project Grant award from the National Eye Institute (NEI), under the CFDA program "Vision Research", provides $132,597 to The Schepens Eye Research Institute, Inc. to investigate the role of neural activity in retinal ganglion cell (RGC) integration and functional connectivity to improve RGC replacement therapies for glaucoma. The research aims to 1) characterize retinal remodeling following RGC inactivation, and 2) determine if inhibiting host neural activity can...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Johns Hopkins University a Vision Research grant (CFDA 93.867) totaling $173,286.17 to evaluate the regenerative potential of human retinal ganglion cells (RGCs). This project, which commenced June 1, 2025, addresses a critical barrier to vision restoration by investigating whether intrinsic factors regulating RGC survival and neurite outgrowth can be modulated to promote axonal regeneration and optic nerve...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $255,340 through the Vision Research program (CFDA 93.867) to The Regents of the University of California, San Francisco for a five-year project (May 1, 2026 – April 30, 2031) focused on understanding and regenerating retinal ganglion cells in the vertebrate retina. This research addresses glaucoma, which affects over four million Americans and represents the second leading cause of irreversible blindness globally. The...
- This federal Project Grant award of $168,396.00 was provided by the National Eye Institute, under the Vision Research federal grant program (CFDA 93.867), to study the cellular and molecular mechanisms underlying lens injury-mediated protection and regeneration of retinal ganglion cells (RGCs) following optic nerve crush injury. The key objectives of this research project are to investigate the role of alpha-crystallin proteins, which were found to be upregulated in the retina following a...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $440,275 to The Research Foundation for the State University of New York for a two-year project (April 1, 2026 through March 31, 2028) to investigate the interacting proteins involved in retinal ganglion cell (RGC) genesis. The research focuses on identifying and characterizing factors that interact with ATOH7, a transcription factor essential for RGC development during...
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $427,625 to the University of Wisconsin-Madison to conduct research on defining folate-dependent single-cell methylomic and transcriptomic networks in distinct retinal ganglion cell (RGC) types associated with axon regeneration. The research aims to isolate and analyze regenerating versus non-regenerating RGCs to identify molecular profiles that distinguish RGC...
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $679,159 to The Schepens Eye Research Institute, Inc. to support research on "In Vivo Epigenetic Reprogramming of Retinal Ganglion Cells in Aging Mice with Glaucoma". The goal is to investigate how aging increases retinal ganglion cell susceptibility to stress and visual function loss in glaucoma, and to explore the potential of epigenetic reprogramming to reverse this age-related...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The Johns Hopkins University a $695,018 Project Grant effective August 1, 2025, through July 31, 2030, to conduct research on the regulation of retinal ganglion cell regeneration through Müller glia (MG) cell function. The award supports a five-year investigation into how MG cells function as injury-responsive stem cells to enable retinal regeneration, with the ultimate goal...
- Federal Project Grant Award Summary The Medical College of Wisconsin, Inc. received a $856,698 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded on July 1, 2025, with a project completion date of March 31, 2030. This award supports mechanistic research into retinal ganglion cell (RGC) genesis, addressing a critical gap in understanding the developmental factors necessary for generating these specialized neurons that serve as the sole...
MEASURING RETINAL GANGLION CELL SPIKE RESPONSES IN THE INTACT PERFUSED EYE FOLLOWING OPTIC NERVE INJURY - PROJECT SUMMARY INJURIES TO THE OPTIC NERVE DAMAGE OR SEVER THE AXONS OF RETINAL GANGLION CELLS (RGCS), LEADING TO VISION LOSS THAT IS CURRENTLY IRREVERSIBLE. WHILE OPTIC NERVE REGENERATION IN A MAJOR RESEARCH AREA, LITTLE IS KNOWN ABOUT THE EARLY FUNCTIONAL CHANGES TO RGCS THAT PRECEDE CELL DEATH. STRATEGIES TO RESTORE VISION, AS WELL AS IMPROVED DIAGNOSTICS, REQUIRE MORE DETAILED INFORMATION ABOUT THE TIME COURSE OF CHANGES IN RGC SPIKE RESPONSES AFTER OPTIC NERVE INJURY. I PROPOSE TO ADDRESS THIS KNOWLEDGE GAP BY DEVELOPING A NEW PREPARATION OF THE INTACT MOUSE EYE AND ITS SUPPORTING VASCULATURE. WE ARE WORKING TO ADAPT AN ISOLATED, PERFUSED EYE PREPARATION THAT HAS BEEN PUBLISHED IN LARGER EYES, INTO THE MOUSE WHILE SIMULTANEOUSLY USING HIGH-DENSITY ELECTRODES TO RECORD SPIKES FROM THE OPTIC NERVE. AIM 1 WILL VALIDATE THE SUCCESSFUL FUNCTIONAL IDENTIFICATION OF RGCS USING OPTO-TAGGING. AIM 2 WILL MEASURE THE TIME COURSE OF DYSFUNCTION IN IDENTIFIED RGCS FOLLOWING OPTIC NERVE CUT WHILE EXPERIMENTALLY VARYING THE LOCATION OF THE CUT ALONG THE NERVE. THE SUCCESSFUL COMPLETION OF THIS PROJECT WILL ESTABLISH A NEW PREPARATION WITH ADVANTAGES OVER EXISTING PREPARATIONS FOR STUDIES OF THE EARLIEST RGC DYSFUNCTION IN RETINAL DISEASE.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $178.7k | 4/10/25 | ||
| Not listed | $224.3k | 4/16/24 | ||
| Not listed | $224.3k | 4/16/24 |