Project Grant R21EY035483
- Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $417,162 to the University of Houston System for a two-year project (July 1, 2025 – June 30, 2027) investigating the birefringence properties of the lamina cribrosa and posterior eye structures as they relate to glaucoma detection and diagnosis. The project addresses a critical clinical need by developing advanced optical imaging methodologies to detect early structural and stress-related changes...
- Federal Grant Award Summary Eye C Better Corp received a $315,825 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025, with a completion date of May 31, 2027. The project develops Photonic Intraocular Pressure (IOP) Biomonitoring (PIB), a non-invasive, non-contact tonometry method for measuring intraocular pressure in glaucoma patients. The technology uses sound wave-induced scleral oscillations detected through...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $643,357 to Massachusetts General Hospital's Research Management Division to develop and validate a novel Brillouin microscopy-based imaging system for direct measurement of corneal hydration. The project, awarded June 15, 2026, with completion targeted for March 31, 2030, addresses a critical clinical gap in current ophthalmic practice: the inability to directly assess...
- The National Eye Institute (NEI) awarded $764,881 to the University of Colorado-Denver under the Vision Research program (CFDA 93.867) on September 15, 2025, to support a two-year research project investigating the role of advanced glycation end products (AGEs) in primary open-angle glaucoma (POAG). The project will generate fundamental research findings and preclinical data on how AGEs accumulate in trabecular meshwork (TM) tissues and contribute to elevated intraocular pressure and optic nerve...
- Grant Award Summary The National Eye Institute (NEI) awarded a $902,000 Project Grant to The Regents of the University of California, San Francisco, effective September 1, 2025, through August 31, 2027, under the Vision Research program (CFDA 93.867). This award funds the multimodal characterization of a novel inherited mouse model of glaucoma to advance understanding of primary open-angle glaucoma (POAG), a leading cause of irreversible blindness affecting over 80 million people worldwide....
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded the University of Maryland, Baltimore $571,206 in project grant funding (awarded May 1, 2026; completion March 31, 2030) to develop, refine, and validate sensitive and robust adaptive optics-optical coherence tomography (AO-OCT) biomarkers for glaucoma detection and progression monitoring. The project addresses a critical clinical need for earlier detection of glaucoma...
- Federal Project Grant Summary The National Eye Institute (NEI) awarded a $427,625 Project Grant to Washington University's Office of Sponsored Research Services effective April 1, 2026, through March 31, 2028, under the Vision Research program (CFDA 93.867). This project develops and delivers novel statistical methodologies to improve early detection and characterization of primary open-angle glaucoma (POAG) progression using longitudinal visual field data from the Ocular Hypertension...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded Outflowgen LLC a $311,049 Phase I Small Business Technology Transfer (STTR) Project Grant on July 15, 2026, under the Vision Research program (CFDA 93.867) to develop a novel one-time CRISPR/Cas9 gene therapy for glaucoma treatment. The project, titled "OutflowGen: One-Time CRISPR Therapy for Glaucoma," will deliver a lipid nanoparticle-encapsulated therapy targeting ROCK1/2 genes, administered via intracameral...
- Project Grant Award Summary The National Eye Institute (NEI) awarded a $527,987 Project Grant to the University of California, Los Angeles, effective May 1, 2026, through April 30, 2030, under the Vision Research program (CFDA 93.867). The award funds development of an engineered adhesive hydrogel biomaterial designed to deliver and enhance mesenchymal stem cell (MSC) function for corneal regeneration. The proposed solution addresses a critical gap in corneal repair therapy by developing a...
- This $599,056 Project Grant, awarded October 1, 2025, by the National Science Foundation (NSF) Directorate for Engineering under CFDA 47.041 (Engineering), funds fundamental research on the biomechanics of aqueous vein flow in the eye. The three-year project, executed by the University of Michigan-Dearborn and concluding September 30, 2028, aims to generate quantitative data on fluid dynamics and mechanical strain in ocular drainage pathways to inform improved glaucoma treatment strategies....
DEVELOPMENT OF ROBUST CORNEAL BIOMECHANICAL BIOMARKERS FOR GLAUCOMA USING BRILLOUIN MICROSCOPY - PROJECT SUMMARY: WHILE ELEVATED INTRAOCULAR PRESSURE (IOP) IS THE ONLY MODIFIABLE RISK FACTOR FOR GLAUCOMA, UP TO ONE THIRD OF PATIENTS HAVE GLAUCOMA AT NORMAL IOPS AND PATIENTS WITH OCULAR HYPERTENSION MAY HAVE HIGH IOP FOR YEARS WITHOUT ANY DETECTABLE GLAUCOMA DAMAGE. THIS IS IN PART BECAUSE, IN BIOMECHANICAL TERMS, THE IOP DESCRIBES THE APPLIED FORCE OR STRESS APPLIED TO THE OCULAR TISSUES BUT NOT THE EFFECT OF THE APPLIED FORCE, THE DEFORMATION OR STRAIN. DIFFERENCES IN INTRINSIC BIOMECHANICAL PROPERTIES OF COLLAGENOUS OCULAR TISSUES MAY EXPLAIN THE DIFFERENCE IN RESPONSE TO THE STRESS OF IOP. WHILE PRIOR WORK HAS SHOWN SOME DIFFERENCES IN THE CORNEAL BIOMECHANICAL PROPERTIES BETWEEN GLAUCOMA SUBJECTS AND CONTROLS, THE WIDESPREAD ADOPTION OF CORNEAL BIOMECHANICS AS GLAUCOMA BIOMARKERS HAS BEEN HAMPERED BY THE LIMITATIONS OF CURRENT TECHNOLOGIES. SPECIFICALLY, THE CURRENTLY USED MODALITIES RELY ON MECHANICAL PERTURBATIONS OF THE CORNEA WHICH GIVE VARIABLE RESULTS THAT ARE CONFOUNDED BY IOP. THE RATIONALE UNDERLYING THIS PROPOSAL IS THAT BRILLOUIN MICROSCOPY, A HIGHLY PRECISE, IOP-INDEPENDENT, AND MORE DIRECT METHOD FOR DETERMINING CORNEAL BIOMECHANICS, WILL IMPROVE OUR UNDERSTANDING OF GLAUCOMA BIOMECHANICS AND THAT ITS USE WILL RESULT IN ROBUST BIOMARKERS FOR THE DISEASE. IN SPECIFIC AIM 1, WE WILL COMPARE THE BRILLOUIN CORNEAL MODULUS IN A CROSS-SECTIONAL STUDY OF PRIMARY OPEN ANGLE GLAUCOMA (POAG) PATIENTS AND AGE-MATCHED CONTROLS. WE HYPOTHESIZE THAT THE BRILLOUIN CORNEAL MODULUS WILL BE SIGNIFICANTLY LOWER IN EYES WITH POAG, INDICATING A CORNEA THAT IS LESS STIFF. IN SPECIFIC AIM 2 WE WILL CONDUCT A LONGITUDINAL STUDY TO ASSESS THE EFFECT OF SHORT-TERM USE OF TOPICAL PROSTAGLANDIN ANALOGS (PGA) ON THE CORNEAL MODULUS IN POAG PATIENTS AND CONTROLS. WE EXPECT THAT PGA USE WILL RESULT IN A REDUCED CORNEAL MODULUS (I.E. A DECREASE IN CORNEAL STIFFNESS), WHICH HAS IMPORTANT IMPLICATIONS IN TERMS OF ASSESSING THE IOP TARGETS AND TREATMENT SUCCESS AFTER USE OF PGAS. WE PLAN TO USE THE RESULTS OF THIS STUDY AS PRELIMINARY DATA FOR A LARGER, LONGER-TERM, AND MORE COMPREHENSIVE STUDY TO ESTABLISH CORNEAL BIOMECHANICS AS ROBUST BIOMARKERS FOR THE DISEASE.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 6/24/26 | ||
| Not listed | $141.1k | 8/4/25 | ||
| Not listed | $230.4k | 6/17/24 |