Project Grant R21EY035468
- This $148,568 Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research at Emory University to investigate the role of scleral fibroblasts in refractive development and myopia. The primary objectives are to: 1) Identify characteristics of scleral fibroblasts in mouse eyes that undergo normal refractive development versus those exposed to myopic stimuli, and 2) Determine the role of retinoic acid signaling in driving...
- Federal Grant Award Summary Emory University received a $391,250 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective July 1, 2025, through June 30, 2030. The grant supports research investigating how visual input influences neuronal signaling pathways in myopia development. The project will employ single-cell electrophysiological recordings to examine ON and OFF retinal pathways—the fundamental mechanisms through which the visual system...
- Grant Award Summary Emory University received a $617,201 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective July 1, 2025, through March 31, 2030, to conduct the AXON (Axonal Biomechanix to Unveil Injury Mechanisms in Glaucomatous Optic Neuropathy) research project. The project will deliver advanced research services combining engineering, artificial intelligence, and optical coherence tomography (OCT) imaging to investigate axonal...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $764,881 to The Regents of the University of Colorado (University of Colorado-Denver) on September 15, 2025, for a two-year project grant extending through September 14, 2027. This research initiative investigates the role of Advanced Glycation End Products (AGEs) in Primary Open-Angle Glaucoma (POAG), the most common form of glaucoma affecting approximately 80% of glaucoma...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $902,000 to the University of California, San Francisco (UCSF) for a two-year project (September 1, 2025 – August 31, 2027) to conduct multimodal characterization of a novel inherited mouse model of glaucoma. The research addresses a critical gap in glaucoma therapeutics by utilizing GLIS1 knockout (KO) mice to study ocular hypertension-induced neurodegeneration without...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded the University of Missouri System $422,199 on July 1, 2025, for a two-year project addressing meibomian gland dysfunction (MGD). This research initiative targets sex hormone receptors as a therapeutic approach to treat MGD, the leading cause of dry eye disease (DED) worldwide. The project investigates the crosstalk regulation between estrogen receptor (ER) and androgen...
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $679,159 to The Schepens Eye Research Institute, Inc. to support research on "In Vivo Epigenetic Reprogramming of Retinal Ganglion Cells in Aging Mice with Glaucoma". The goal is to investigate how aging increases retinal ganglion cell susceptibility to stress and visual function loss in glaucoma, and to explore the potential of epigenetic reprogramming to reverse this age-related...
- Federal Project Grant Award Summary Baylor College of Medicine received a $568,122 Project Grant from the National Eye Institute under the Vision Research program (CFDA 93.867), effective July 1, 2025 through March 31, 2030. The award funds research into the role of vascular ligands and neurovascular dysfunction in glaucoma pathogenesis and therapeutic development. The project will deliver comprehensive mapping of cell-binding ligands across ocular hypertension and healthy retinal endothelial...
- This $387,428 Project Grant from the National Eye Institute (CFDA 93.867 - Vision Research) aims to investigate fundamental mechanisms driving optic nerve sensitivity to elevated intraocular pressure, a major risk factor for optic nerve damage in glaucoma. The project will use 3D bioengineering tools, transgenic animal models, and ex vivo donor optic nerve head tissue to test the hypothesis that transient biomechanical strains prime optic nerve head astrocytes to develop greater glaucomatous...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $481,250 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective June 1, 2025 through May 31, 2027. The award funds research investigating the molecular mechanisms by which mutations in the ADAMTS10 gene contribute to primary open-angle glaucoma (POAG), a leading cause of irreversible blindness. The research employs genetically modified mouse models carrying...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research (CFDA 93.867) program is providing $438,018 to Emory University to investigate the impact of age, sex, and menopause on scleral biomechanics and gene expression related to glaucoma risk. The 2-year project aims to measure scleral mechanical properties and assess gene expression profiles in a rat model across young, older adult, and surgically menopausal groups. This research aims to provide functional and mechanistic insights into how age and menopause modulate ocular biomechanics and gene networks, with the goal of identifying potential targets for treatments to reduce glaucoma susceptibility. Emory University is collaborating with Georgia TECH Research Corporation on a $43,000 sub-award to support the gene expression analysis component of the project.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $438.0k | 9/6/23 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
A888054S | Georgia TECH Research Corp | Project Grant R21EY035468 | $33.2k | 1/13/25 |