This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) in the amount of $386,676 supports research to characterize the role of small MAF transcription factors MAFG and MAFK, and their co-regulator NRF2, in lens development and their impact on the function of the human cataract-linked transcription factor C-MAF. The research will utilize mouse models including MAFG/KDKO, MAFG/KCPKO, and NRF2CKO to define the etiology of lens cellular defects and cataract,...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to combine optical coherence elastography (OCE) and Brillouin microscopy techniques to evaluate in vivo lens biomechanics in presbyopia. The $374,020 award, with a period of performance from July 1, 2024 to March 31, 2025, aims to develop a combined OCE/Brillouin system capable of quantitatively measuring depth-dependent elastic moduli of the lens. This...
This $148,568 Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) to Emory University supports research to investigate the role of scleral fibroblasts in refractive development and myopia. The research aims to identify characteristics of scleral fibroblasts that contribute to successful refractive development, and then compare those to changes observed in mouse models of myopia induced by lens wear or retinoic acid exposure. This work will help elucidate the role of...
This federal Project Grant award of $237,588.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to understand the neural mechanisms underlying sensory encoding and visual behaviors after photoreceptor degeneration. The project aims to characterize the impact of cone loss on noise correlations in motion-sensitive retinal ganglion cells and how this affects the optokinetic reflex, a visual behavior that tracks global motion. The research will leverage the cone-DTR...
The National Eye Institute (NEI) awarded a $248,999 Project Grant (CFDA 93.867 - Vision Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, with a project period from May 1, 2025 to April 30, 2028. The grant supports research to investigate how neuronal synaptic activity, particularly glutamatergic signaling, regulates retinal angiogenesis and blood-retina barrier (BRB) maturation during postnatal development. The research aims to elucidate the...
The National Eye Institute (NEI), under the Federal Grant Program CFDA 93.867 (Vision Research), awarded a Project Grant in the amount of $458,517 to The Ohio State University on July 1, 2024. The grant supports a 5-year research project to investigate the interactions between neutrophils and monocytes that result in monocyte polarization towards an arginine-positive, reparative phenotype. This research aims to understand the underlying signals that drive monocytes to take on a neuroprotective...
This federal Project Grant award for $2,174,069 from the National Eye Institute (NEI) Vision Research program (CFDA 93.867) is supporting research to elucidate the regenerative potential of the corneal endothelium and devise innovative therapeutic interventions for Fuchs' Endothelial Corneal Dystrophy (FECD). The research aims to stimulate corneal endothelial cell (CEC) proliferation in vivo to renew the corneal endothelium and restore corneal transparency and vision for FECD patients. Key...
This $429,016 federal Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) to Oakland University supports research to identify the mechanisms by which a subset of retinal amacrine cells, called starburst amacrine cells, initiate and propagate spontaneous cholinergic waves in the developing retina. The objectives are to determine the distribution and properties of these cholinergic wave "pacemaker" cells (Aim 1) and to elucidate the calcium-dependent...
The National Eye Institute (NEI) awarded Miami University a $214,227 Project Grant (CFDA 93.867 - Vision Research) to decode the transcriptional regulation of the FOXE3 gene during lens development. The project aims to identify and functionally test the cis-regulatory elements and transcription factors that control FOXE3 expression in the chick and mouse lens. This research seeks to enhance the utility of the chick lens model for screening gene and enhancer function through the development of...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports a collaboration between the University of Northern Colorado (UNC) and researchers to develop novel biophysical models of eye morphogenesis processes. The $413,920 award, effective August 1, 2024 through July 31, 2027, will fund the creation and validation of quantitative models for choroid fissure closure in zebrafish and foveal pit formation across species. Key...