Project Grant R21ES038308
- The National Institute of Environmental Health Sciences awarded Boston University Medical Campus $197,600 on November 1, 2025, under the Environmental Health program (CFDA 93.113) to examine early-life exposure to ferroalloy metal mixtures and adolescent cognition. The research investigates how exposure to neuroactive metals—manganese, lead, chromium, and copper—released through ferroalloy industrial emissions affects neurodevelopment in children and adolescents living near such facilities....
- The National Institute of Environmental Health Sciences awarded Central Michigan University $394,165 on June 11, 2026, under the Environmental Health program (CFDA 93.113) to investigate how methylmercury exposure disrupts neural circuits controlling emotion and cognition in the prefrontal and insular cortices. The research applies an integrative approach combining systems neurophysiology, synaptic, and molecular-level analysis to determine in vivo effects of methylmercury on these brain...
- The National Institute of Environmental Health Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded $815,546 to Icahn School of Medicine at Mount Sinai on June 22, 2026, under the Environmental Health program (CFDA 93.113) to investigate how early-life chemical exposures affect executive function and brain development across adolescence. The research leverages naturally shed deciduous teeth as biomarkers to measure in utero and early childhood...
- The National Institute of Environmental Health Sciences awarded The Trustees of Columbia University in the City of New York $126,355 on August 4, 2026, under the Environmental Health program (CFDA 93.113) to assess tissue-specific responses to metal exposure in humans through development of a blood-based biomarker framework. The funded research establishes whether two recently developed diagnostic tools—the Organ Age Clock (OrgAnge), which uses organ-specific proteins in plasma to estimate...
- The National Institute of Environmental Health Sciences awarded Emory University $148,614 on February 16, 2026, under the Environmental Health program (CFDA 93.113) to investigate the joint effects of prenatal pesticide exposure and psychosocial factors on epigenetic age trajectories and child psychopathology in a South African birth cohort. The study uses advanced environmental mixture methods to analyze longitudinal data from the Drakenstein Child Health Study, a low-resource-setting birth...
- The National Institute of Environmental Health Sciences awarded $795,869 to Regents of the University of Michigan on April 16, 2026, under the Environmental Health program (CFDA 93.113) to investigate volatile organic compound impacts on immune functions during pregnancy and identify molecular mechanisms for potential interventions. The research examines how environmental toxicants, specifically trichloroethylene (TCE) and perchloroethylene (PCE), disrupt immune defenses in the uterus, fetal...
- The National Institute of Environmental Health Sciences awarded The University of Texas Southwestern Medical Center $649,193 on April 1, 2026, under the Environmental Health program (CFDA 93.113, Project Grant R01ES038329) to investigate molecular mechanisms of epitranscriptomic dysregulation induced by toxic metals. The research examines how naturally occurring heavy metals—arsenic, cadmium, chromium, and nickel—impact post-transcriptional gene regulation through RNA modifications and...
- The National Institute of Environmental Health Sciences awarded Michigan State University $402,066 on September 27, 2025, under the Environmental Health program (CFDA 93.113) to investigate how the epicardium and the IRE1 signaling pathway mediate the effects of environmental chemical exposure on cardiac function. The project employs three-dimensional human heart organoids derived from induced pluripotent stem cells to model the impact of per- and polyfluoroalkyl substances (PFAS) on lipid...
- The National Institute of Environmental Health Sciences awarded Michigan State University $144,254 on February 1, 2026, under the Environmental Health program (CFDA 93.113) to support postdoctoral training and research on metabolism disrupting chemical exposures and maternal metabolic health in pregnancy. The award funds comprehensive training for Maria Cinzori in environmental epidemiology and perinatal health research, with mentorship from an interdisciplinary team experienced in environmental...
- The National Institute of Environmental Health Sciences awarded The Trustees of Columbia University in the City of New York $942,408 on June 1, 2026, under the Environmental Health program (CFDA 93.113) to develop novel metalloproteomics biomarkers and integrate them into observational and experimental studies to assess the role of metals in aging and brain health outcomes. The award funds development of mass spectrometry technologies to quantify metal-protein interactions, stable isotope...
The National Institute of Environmental Health Sciences awarded $429,000 to the Regents of the University of Michigan on September 2, 2026, to investigate early life toxicant and psychosocial co-exposures and their associations with adolescent and emerging adult mental health, under the Environmental Health program (CFDA 93.113), with performance through September 1, 2028. The research uses the ELEMENT cohort, a longitudinal scientific resource with over 30 years of follow-up and extensive prenatal biospecimens, to examine how heavy metal exposures and psychosocial risk and protective factors in early life influence mental health in emerging adulthood. The investigation focuses on the synergistic effects of metals and psychosocial risk exposures, and the potential protective buffering of positive psychosocial factors, through their impact on physiological stress pathways during sensitive developmental periods such as adolescence. The study will assess associations of metals and psychosocial exposure mixtures with physiological stress biomarkers, including oxidative stress and allostatic load. Work is performed at the University of Michigan, Ann Arbor, Michigan. The award is a Project Grant, an assistance type supporting investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 9/2/26 |